Paradoxes in leaky microbial trade
Paradoxes in leaky microbial trade
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DOI：
10.1038/s41467-017-01628-8
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发表时间：
2017-11-08
影响因子：
16.6
通讯作者：
Libby, Eric
中科院分区：
文献类型：
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作者：
Kallus, Yoav;Miller, John H.;Libby, Eric
微生物产生对细胞生长很重要的代谢资源，但又会泄漏到环境中。其他微生物可以利用这些资源，相应地调整自己的新陈代谢产物，并改变可供其他微生物使用的资源。我们分析了一个模型，在该模型中，代谢物浓度、生产调节和种群频率在两种细胞类型产生两种代谢物的简单情况下共同进化。我们发现了三个悖论，在这些变化中，直觉上有利于一种细胞类型的变化实际上损害了它。例如，一种细胞类型在生产代谢物方面可以变得更有效，其相对频率可能会降低，或者总的种群增长率可能会降低。另一个悖论是，当一种细胞类型操纵其对应细胞的产量以最大化其自身的瞬时增长率时，最终的增长率却低于没有被操纵的细胞类型。这些悖论突显了在简单的微生物经济中出现的复杂和违反直觉的动态。
Microbes produce metabolic resources that are important for cell growth yet leak into the environment. Other microbes can use these resources, adjust their own metabolic production accordingly, and alter the resources available for others. We analyze a model in which metabolite concentrations, production regulation, and population frequencies coevolve in the simple case of two cell types producing two metabolites. We identify three paradoxes where changes that should intuitively benefit a cell type actually harm it. For example, a cell type can become more efficient at producing a metabolite and its relative frequency can decrease-or alternatively the total population growth rate can decrease. Another paradox occurs when a cell type manipulates its counterpart's production so as to maximize its own instantaneous growth rate, only to achieve a lower final growth rate than had it not manipulated. These paradoxes highlight the complex and counterintuitive dynamics that emerge in simple microbial economies.