RAT SALIVARY-GLAND BLOOD-FLOW AND BLOOD-TO-TISSUE PARTITION-COEFFICIENTS FOLLOWING X-IRRADIATION
RAT SALIVARY-GLAND BLOOD-FLOW AND BLOOD-TO-TISSUE PARTITION-COEFFICIENTS FOLLOWING X-IRRADIATION
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DOI：
10.1016/0003-9969(94)90038-8
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发表时间：
1994-01-01
影响因子：
3
通讯作者：
BAUM, BJ
中科院分区：
文献类型：
--
作者：
HIRAMATSU, Y;NAGLER, RM;BAUM, BJ
本文观察了单次大剂量X射线(15GyX射线)照射成年雄性大鼠头颈部的效应。照射后3天，经股静脉注入[C-14]-碘安替比林(IAP)。之后，动物在指定的时间被宰杀，三个主要唾液腺被摘除。用药代动力学模型分析了这些组织对IAP的摄取。与非辐射对照组和配对喂养组的结果相比，辐射对所有测量变量的影响相对较小。
Effects of a single high dose of X-irradiation (15 Gy) to the head and neck region in adult male rats were examined. Three days after radiation, rats were infused with [C-14]-iodoantipyrine (IAP) via the femoral vein. Animals were killed at designated times thereafter and the three major salivary glands removed. The uptake of IAP by these tissues was analysed using a pharmacokinetic model. Radiation had relatively modest effects on all measured variables when compared with results from the non-irradiated control and pair-fed groups.