ASSESSMENT OF 3 AZOPHENOL CALIX[4]ARENES AS CHROMOGENIC LIGANDS FOR OPTICAL-DETECTION OF ALKALI-METAL IONS
ASSESSMENT OF 3 AZOPHENOL CALIX[4]ARENES AS CHROMOGENIC LIGANDS FOR OPTICAL-DETECTION OF ALKALI-METAL IONS
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DOI：
10.1039/an9931801127
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发表时间：
1993-09-01
期刊：
影响因子：
4.2
通讯作者：
DIAMOND, D
中科院分区：
文献类型：
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作者：
MCCARRICK, M;HARRIS, SJ;DIAMOND, D
合成了三种新的显色锥构象杯[4]芳烃四酯，其酯部分含有硝基苯基偶氮苯酚残基（单取代、双取代和四取代），并显示出在碱存在下与锂络合时吸收光谱的显著变化，并且在较小程度上与钠络合。当向含有三种配体中的任何一种的溶液中加入高氯酸锂时，注意到从黄色到红色的瞬时颜色变化，对应于从380到520 nm的λ（max）位移，颜色的强度与浓度有关。单取代的衍生物配体4表现出锂对钠和钾的最佳选择性（在两种情况下选择性均为约70倍）。虽然这比临床应用所需的要少一些，但预计可以使用各种方法进一步改进，这是进一步研究的主题。钾的干扰太小，无法测量。
Three novel chromogenic cone conformational calix[4]arene tetraesters bearing nitrophenylazophenol residues (mono-, di- and tetra-substituted) in the ester portion of the molecules have been synthesized and shown to display a dramatic change in absorbance spectrum upon complexation with lithium, and to a lesser extent sodium, in the presence of a base. An instantaneous colour change from yellow to red corresponding to a lambda(max) shift from 380 to 520 nm, is noted upon the addition of lithium perchlorate to a solution containing any of the three ligands with the intensity of the colour being concentration dependent. The best selectivity for lithium against sodium and potassium was exhibited by the mono-substituted derivative, ligand 4, (approximately 70-fold selectivity in both cases). Although this is somewhat less than that required for clinical applications, it is anticipated that it can be further improved using a variety of approaches, which are the subject of further investigations. The interference from potassium is too small to be measured.