Emotional working memory and Alzheimer's disease.
Emotional working memory and Alzheimer's disease.
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DOI：
10.1155/2014/207698
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发表时间：
2014
影响因子：
--
通讯作者：
Fairfield B
中科院分区：
文献类型：
--
作者：
Mammarella N;Fairfield B
最近的一些研究表明，当涉及情感信息时，健康老年人的工作记忆似乎并没有表现出典型的年龄相关缺陷。然而，关于阿尔茨海默氏症型痴呆症患者短期编码和积极操纵情绪信息的能力的研究很少，并且产生了混合的结果。在这里，我们回顾行为和神经影像学证据，指出阿尔茨海默氏症的情绪调节和工作记忆之间的复杂相互作用。事实上，根据所涉及的功能，患者可能会或可能不会在他们的工作记忆表现中表现出情感上的好处。此外，这种好处并不总是明显的偏见（例如，积极或消极的信息）。我们将这种复杂的结果模式解释为多种因素之间相互作用的结果，包括阿尔茨海默病的严重程度，情感刺激的性质和工作记忆任务的类型。
A number of recent studies have reported that working memory does not seem to show typical age-related deficits in healthy older adults when emotional information is involved. Differently, studies about the short-term ability to encode and actively manipulate emotional information in dementia of Alzheimer's type are few and have yielded mixed results. Here, we review behavioural and neuroimaging evidence that points to a complex interaction between emotion modulation and working memory in Alzheimer's. In fact, depending on the function involved, patients may or may not show an emotional benefit in their working memory performance. In addition, this benefit is not always clearly biased (e.g., towards negative or positive information). We interpret this complex pattern of results as a consequence of the interaction between multiple factors including the severity of Alzheimer's disease, the nature of affective stimuli, and type of working memory task.