Life-Span Extension by Caloric Restriction Is Determined by Type and Level of Food Reduction and by Reproductive Mode in Brachionus manjavacas (Rotifera)
Life-Span Extension by Caloric Restriction Is Determined by Type and Level of Food Reduction and by Reproductive Mode in Brachionus manjavacas (Rotifera)
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DOI：
10.1093/gerona/gls170
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发表时间：
2013-04-01
影响因子：
5.1
通讯作者：
Welch, David B. Mark
中科院分区：
文献类型：
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作者：
Gribble, Kristin E.;Welch, David B. Mark
我们测量了在一定食物浓度范围内的慢性热量限制(CCR)和间歇性禁食(IF)条件下，三种繁殖模式的单角轮虫克隆的寿命和繁殖力。如果三种模式的寿命都增加了50%-70%，而CCR则增加了有性或无性产卵的无性雌性的寿命，但不能延长有性雌性的寿命。在这两种无性模式中，CR的主要作用是延缓幼年死亡，而不是防止中年死亡或大大延长最大寿命；相反，有性雌性CR大大延长了少数长寿个体的寿命。终生繁殖力没有随着CCR的增加而降低，这表明在体细胞维持和繁殖之间缺乏资源分配的权衡。克隆谱系的多重结果表明，不同的反应是通过表观遗传编程建立的，而寿命分配的差异表明，多种遗传机制介导了寿命的延长。
We measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension.