Construction of Thienopyrroles through Rhodium-Catalyzed Direct Annulation of (Acetylamino)thiophenes with Alkynes
Construction of Thienopyrroles through Rhodium-Catalyzed Direct Annulation of (Acetylamino)thiophenes with Alkynes
复制标题
通过铑催化（乙酰氨基）噻吩与炔烃的直接成环反应构建噻吩并吡咯
DOI：
10.1055/a-2015-4466
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tetsuya Satoh
中科院分区：
文献类型：
--
作者：
Mikishiro Hayashi;Ryudai Michikita;Yoshinosuke Usuki;Tetsuya Satoh
在铑催化下，3-（乙酰氨基）噻吩与内炔的直接环状偶联通过乙酰氨基定向的C2-位C-H键断裂顺利进行，从而有效构建了4-乙酰基噻吩并[3，2-B]吡咯衍生物。环化产物上的乙酰基导向基团容易除去，产生4-未保护的噻吩并[3，2-B]吡咯衍生物。
The direct annulative coupling of 3-(acetylamino)thiophenes with internal alkynes proceeds smoothly under rhodium catalysis through acetylamino-directed C–H bond cleavage at the C2-position, leading to the effective construction of 4-acetylthieno[3,2-b]pyrrole derivatives. The acetyl directing group on the annulation product is readily removed to produce the 4-unprotected thieno[3,2-b]pyrrole derivative.