Nonrespiratory Comorbidities in Asthma.

Nonrespiratory Comorbidities in Asthma.
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DOI:
10.1016/j.jaip.2021.08.027
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发表时间:
2021-11
期刊:
The journal of allergy and clinical immunology. In practice
影响因子:
--
通讯作者:
Lockey RF
Lockey RF
中科院分区:
其他
文献类型:
--
作者:
Cardet JC;Bulkhi AA;Lockey RF

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哮喘是一种慢性异质性呼吸道疾病。常见的合并症通常不成比例地出现在严重哮喘中。对哮喘患者的最佳护理需要认识到这些并存情况并进行治疗。本文概述了非呼吸道合并症与哮喘之间的病理生理机制及其对哮喘预后的影响。这些疾病包括:2型糖尿病、高血压、动脉粥样硬化性心血管疾病、肾上腺和甲状腺疾病、妊娠、骨质疏松症、药物不良反应和精神健康障碍。研究表明,2型糖尿病血糖控制不佳不仅与更高的医疗保健利用率有关,而且与更差的哮喘结果有关。此外,一个大型医疗保健索赔数据库表明,相当大比例的孕妇患有未得到控制的哮喘,并被开出次优的控制器治疗处方。关于这些非呼吸道合并症和已知对非呼吸道合并症和哮喘都有好处的药物的更多数据是必要的。
Asthma is a chronic heterogeneous airway disease. Common comorbid conditions are often disproportionately present in severe asthma. Optimal care of patients with asthma requires the recognition and treatment of these comorbid conditions. This review outlines the pathophysiologic mechanisms between non-respiratory comorbid conditions and asthma and their effect on asthma outcomes. They include: type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease, adrenal and thyroid gland diseases, pregnancy, osteoporosis, adverse effects from medications, and mental health disorders. Studies indicate how poor glycemic control of type 2 diabetes mellitus is not only associated with greater healthcare utilization but poorer asthma outcomes. Also, a large healthcare claims database indicates that a substantial proportion of pregnant women have uncontrolled asthma and are prescribed suboptimal controller therapy. Additional data about these non-respiratory comorbidities and medications known to benefit both non-respiratory comorbidities and asthma are necessary.
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