Paneth cell-like metaplasia of the prostate gland.
Paneth cell-like metaplasia of the prostate gland.
复制标题
前列腺潘氏细胞样化生。
DOI：
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发表时间：
1992
影响因子：
4.6
通讯作者：
N. Brazenas
中科院分区：
文献类型：
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作者：
C. Frydman;Ira J. Bleiweiss;Pamela D. Unger;Ronald E. Gordon;N. Brazenas
我们报告两例潘氏细胞样化生的前列腺，一个在低分化癌和良性增生第二。光镜下，潘氏样细胞与正常小肠中的潘氏细胞难以区分，超微结构显示潘氏细胞典型的电子致密颗粒。免疫组化染色前列腺特异性抗原和前列腺酸性磷酸酶阳性，溶菌酶和α 1-抗胰蛋白酶阴性。潘氏细胞样化生的临床意义尚不清楚，可能代表了活跃分裂细胞的多潜能化生能力。
We report two cases of Paneth cell-like metaplasia of the prostate gland, one in poorly differentiated carcinoma and the second in benign hyperplasia. By light microscopy, the Paneth-like cells were indistinguishable from Paneth cells found in the normal small intestine and ultrastructurally showed electron-dense granules typical of Paneth cells. Immunohistochemical stains were positive for prostate-specific antigen and prostatic acid phosphatase and negative for lysozyme and alpha 1-antitrypsin. The clinical significance of Paneth cell-like metaplasia is unknown and may represent an example of the multipotential metaplastic capability of actively dividing cells.