New directions in neuroregeneration
New directions in neuroregeneration
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DOI：
10.1517/14712598.6.8.735
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发表时间：
2006-08-01
影响因子：
4.6
通讯作者：
Ming, Guo-li
中科院分区：
文献类型：
--
作者：
Kim, Ju Young;Schafer, Julie;Ming, Guo-li
成年哺乳动物中枢神经系统（CNS）中的神经元在损伤后不能自发地再生其轴突。尽管在轴突再生领域取得了重大进展，但促进损伤后功能恢复的有效治疗策略尚不可用。新疗法的开发将需要进一步深入了解限制成人CNS再生的内在和外在机制。同样重要的是，必须确定介导轴突连接恢复的机制。本文综述了中枢神经系统损伤后神经突起生长抑制的分子机制，并为神经再生研究的未来方向提供了新的见解。
Neurons in the adult mammalian central nervous system (CNS) do not spontaneously regenerate their axons after injury. Despite significant progress in the field of axonal regeneration, effective therapeutic strategies to promote functional recovery after injury are not available. The development of novel therapeutics will require further insights into the intrinsic and extrinsic mechanisms that restrict regeneration in the adult CNS. It is equally important that the mechanisms mediating the restoration of axonal connectivity must be determined. This review summarises the known molecular mechanisms of neurite outgrowth inhibition after CNS injury and provides new insights into the potential future direction of neuroregeneration research.