A COMPUTERIZED BRAIN ATLAS - CONSTRUCTION, ANATOMICAL CONTENT, AND SOME APPLICATIONS
A COMPUTERIZED BRAIN ATLAS - CONSTRUCTION, ANATOMICAL CONTENT, AND SOME APPLICATIONS
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DOI：
10.1097/00004728-199101000-00003
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发表时间：
1991-01-01
影响因子：
1.3
通讯作者：
ERIKSSON, L
中科院分区：
文献类型：
--
作者：
GREITZ, T;BOHM, C;ERIKSSON, L
一个可调节的计算机化人脑图谱已经开发出来，它可以适应个人的解剖结构。 它主要用于正电子发射断层扫描（PET），但也可用于单光子发射CT、透射CT、磁共振成像和基于神经成像的手术，如立体定向手术和放射治疗。 该地图集是基于死后不久固定在原位的大脑所获得的解剖信息。 所有的结构都画在一个冷冻切片的大脑切片的数字化照片上。 解剖结构和分区的定义和分类与解剖学的标准教科书一致，并且命名是1965年的Nomina Anatomica。 皮质cytoarchitectonic区（布罗德曼区）的边界已确定使用来自几个来源的信息，因为它们的分布的三维文献数据是不完整的，稀缺的，部分矛盾。 然而，还没有对寰椎大脑本身的细胞结构进行分析。 目前的数据库包含的三维表示的大脑表面，脑室系统，皮质回和沟，以及布罗德曼cytoarchitectonic地区。 主要的基底神经节、脑干核、小脑蚓部小叶和小脑半球也包括在内。 计算机化图谱可用于以多种方式改善PET数据的量化和评价。 例如，它可以作为选择感兴趣区域的指南。 它还可以通过将逆图谱变换应用于PET数据体积，从而将PET信息与参考图谱的解剖结构而不是患者的解剖结构相关联，来促进来自不同个体或个体组的数据的比较。 因此，可以对来自个体的重新格式化的PET数据进行平均，并且可以比较来自患者的不同类别或不同功能状态的平均值。
An adjustable computerized atlas of the human brain has been developed, which can be adapted to fit individual anatomy. It is primarily intended for positron emission tomography (PET) but may also be used for single photon emission CT, transmission CT, magnetic resonance imaging, and neuroimaging-based procedures, such as stereotactic surgery and radiotherapy. The atlas is based on anatomical information obtained from brains fixed in situ soon after death. All structures have been drawn in on digitized photos of slices from one cryosectioned brain. The definition and classification of the anatomical structures and divisions are in agreement with the standard textbooks of anatomy, and the nomenclature is that of the Nomina Anatomica of 1965. The boundaries of the cortical cytoarchitectonic areas (Brodmann areas) have been determined using information from several sources, since three-dimensional literature data on their distribution are incomplete, scarce, and partly contradictory. However, no analysis of the cytoarchitectonics of the atlas brain itself has been undertaken. At present the data base contains three-dimensional representations of the brain surface, the ventricular system, the cortical gyri and sulci, as well as the Brodmann cytoarchitectonic areas. The major basal ganglia, the brain stem nuclei, the lobuli of the vermis, and the cerebellar hemispheres are also included. The computerized atlas can be used to improve the quantification and evaluation of PET data in several ways. For instance, it can serve as a guide in selecting regions of interest. It may also facilitate comparisons of data from different individuals or groups of individuals, by applying the inverse atlas transformation to PET data volume, thus relating the PET information to the anatomy of the reference atlas rather than to the patient's anatomy. Reformatted PET data from individuals can thus be averaged, and averages from different categories or different functional states of patients can be compared.