Synthesis and biochemical properties of reversible inhibitors of UDP-N-acetylglucosamine 2-epimerase
Synthesis and biochemical properties of reversible inhibitors of UDP-N-acetylglucosamine 2-epimerase
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DOI：
10.1002/anie.200453863
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发表时间：
2004-01-01
影响因子：
16.6
通讯作者：
Giannis, A
中科院分区：
文献类型：
--
作者：
Al-Rawi, S;Hinderlich, S;Giannis, A
唾液酸包括具有由9个碳原子组成的主链骨架的α-酮酸家族。N-乙酰神经氨酸（Neu 5Ac或NANA;见方案1）是最常见的唾液酸，也是几乎所有已知的50种此类成员的生物合成前体。[1]由于唾液酸暴露在寡糖链的远端，唾液酸有助于糖链的生物学特性。
Sialic acids comprise a family of α-keto acids with a backbone skeleton consisting of nine carbon atoms. N-Acetylneuraminic acid (Neu5Ac or NANA; see Scheme 1) is the most common sialic acid and also the biosynthetic precursor of almost all known 50 members of this class.[1] Due to their exposed position at the distal end of oligosaccharide chains, sialic acids contribute to the biological properties of glyco-