Area-specific resonance of excitatory networks in neocortex: Control by outward currents
Area-specific resonance of excitatory networks in neocortex: Control by outward currents
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DOI：
10.1111/j.1528-1167.2007.01113.x
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发表时间：
2007-08-01
期刊：
影响因子：
5.6
通讯作者：
Tawara-Hirata, Yoshie
中科院分区：
文献类型：
--
作者：
Castro-Alamancos, Manuel A.;Tawara-Hirata, Yoshie
在去抑制或低[Mg++](o)缓冲期间，运动（颗粒）皮层中相互连接的锥体细胞的兴奋网络产生7-14 Hz（类似于10 Hz）的振荡，但在桶状（颗粒）皮层中不存在振荡。在这里，我们研究了桶状皮层在这些条件下无法产生类似的10hz振荡是因为桶状皮层网络缺乏必要的细胞机制，或者是因为这些机制被外向电流抑制了。结果表明，缓慢灭活电压依赖性K+电流的阻滞剂与桶状皮层中10 Hz振荡相似，这与被外向电流抑制的固有内向Ca++电流的灭活是一致的。此外，在桶状皮层中发现的类似于10hz的振荡在上层和下层独立发生，这表明类似于10hz的振荡机制在多个网络中被抑制。结果表明，新皮层不同的兴奋网络产生癫痫样振荡活动的倾向是由外向电流控制的。
During disinhibition or low [Mg++](o) buffer, 7-14 Hz (similar to 10 Hz) oscillations are generated by excitatory networks of interconnected pyramidal cells in motor (agranular) cortex but are absent in barrel (granular) cortex. Here we studied if the inability of barrel cortex to produce similar to 10 Hz oscillations during these conditions is because barrel cortex networks lack the necessary cellular mechanisms or, alternatively, because those mechanisms are inhibited by outward currents. The results show that blockers of slowly inactivating voltage-dependent K+ currents unmask similar to 10 Hz oscillations in barrel cortex, and this occurs in unison with the unmasking of intrinsic inward Ca++ currents that are kept suppressed by the outward currents. Moreover, the similar to 10 Hz oscillations unmasked in barrel cortex occur independently in upper and lower layers indicating that the similar to 10 Hz oscillation mechanisms are kept suppressed in multiple networks. The results reveal that the propensity of distinct excitatory networks of neocortex to generate epileptiform oscillatory activities is controlled by outward currents.