EFFECTS OF MEDIAN RAPHE NUCLEUS LESIONS ON HIPPOCAMPAL EEG IN THE FREELY MOVING RAT
EFFECTS OF MEDIAN RAPHE NUCLEUS LESIONS ON HIPPOCAMPAL EEG IN THE FREELY MOVING RAT
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DOI：
10.1016/0006-8993(79)90351-2
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发表时间：
1979-01-01
期刊：
影响因子：
2.9
通讯作者：
IWAHARA, S
中科院分区：
文献类型：
--
作者：
MARU, E;TAKAHASHI, LK;IWAHARA, S
中缝病变，包括那些局限于中缝核的病变，明确产生海马低频θ。放松不动期间的活动（5.8 Hz，SD = 0.47 Hz），这在正常条件下未观察到。这种损伤引起的θ。不动期间的活动持续至少 20 天，并被硫酸阿托品（10 mg/kg，腹腔注射）显着抑制。网状结构损伤对静止、运动或 PS（反常睡眠）期间的海马脑电图模式几乎没有影响。 .theta 的平均频率。中缝损伤后第二天的运动和 PS 活动显着减少。中缝-海马通路，其中中缝核通过对海马 θ 施加抑制影响，在海马去同步化（不规则模式）中发挥主要作用。提出了生成或促进机制。 Theta 活性很可能是由中缝损伤后的去抑制引起的。
Median raphe lesions, including those restricted to the median raphe nucleus, unequivocally produced hippocampal low-frequency .theta. activity (5.8 Hz, SD = 0.47 Hz) during relaxed immobility which was not observed under normal conditions. This lesion-induced .theta. activity during immobility continued for at least 20 days, and was markedly suppressed by atropine sulfate (10 mg/kg, i.p.). Reticular formation lesions had little effect on either hippocampal EEG patterns during immobility, movement or PS [paradoxical sleep]. The mean frequency of .theta. activity was significantly reduced during movement and PS on the day following the median raphe lesion. A raphe-hippocampal pathway in which the median raphe nucleus plays a major role in hippocampal desynchronization (irregular pattern) by exerting an inhibitory influence on the hippocampal .theta. generating or facilitating mechanism was suggested. Theta activity may well be induced by the disinhibition following median raphe lesions.