A NEW CLASS OF UNCOUPLING AGENTS - CARBONYL CYANIDE PHENYLHYDRAZONES
A NEW CLASS OF UNCOUPLING AGENTS - CARBONYL CYANIDE PHENYLHYDRAZONES
复制标题
DOI：
10.1016/0006-291x(62)90189-4
复制
发表时间：
1962-01-01
影响因子：
3.1
通讯作者：
PRICHARD, WW
中科院分区：
文献类型：
--
作者：
HEYTLER, PG;PRICHARD, WW
虽然使用来自几种动物和植物来源的新鲜制备的线粒体获得了几乎相同的结果，但冻融的制剂（例如牛心线粒体）对羰基氰苯腙 (CCP) 解偶联剂和 2,4-二硝基苯酚更敏感。在吩嗪硫酸甲酯存在下，分离的菠菜叶绿体的光磷酸化也受到 CCP 解偶联剂的强烈抑制。
While almost identical results were obtained with freshly prepared mitochondria from several animal and plant sources, frozen-thawed preparations (e.g. beef heart mitochondria) were somewhat more sensitive to the carbonyl cyanide phenylhydrazones (CCP) uncouplers and to 2,4-dinitrophenol. Photo-phosphorylation by isolated spinach chloroplasts in the presence of phenazine methosulfate is also strongly inhibited by CCP uncouplers.