Reflections on the clonal-selection theory
Reflections on the clonal-selection theory
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DOI：
10.1038/nri2177
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发表时间：
2007-10-01
影响因子：
100.3
通讯作者：
Weigert, Martin
中科院分区：
文献类型：
--
作者：
Cohn, Melvin;Mitchison, N. Av;Weigert, Martin
我们如何解释免疫系统对新抗原产生抗体的能力？50年前，f·麦克法兰·伯内特（F. Macfarlane Burnet）发表了他对这个问题的答案：抗体多样性的克隆选择理论。不同抗原的特异性在遇到这些抗原之前就存在，这在当时是一个激进的观点，但后来被广泛接受。在这篇文章中，Nature Reviews Immunology询问了六位重要的科学家关于克隆选择理论的想法和观点，从它的第一次提出到他们今天对它的看法。
How do we account for the immune system's ability to produce antibodies in response to new antigens? It has been 50 years since F. Macfarlane Burnet published his answer to this question: the clonal-selection theory of antibody diversity. The idea that specificity for diverse antigens exists before these antigens are encountered was a radical notion at the time, but one that became widely accepted. In this article, Nature Reviews Immunology asks six key scientists for their thoughts and opinions on the clonal-selection theory, from its first proposal to their views of it today.