Assembled Vitamin B2 Nanocrystals with Optical Waveguiding and Photosensitizing Properties for Potential Biomedical Application
Assembled Vitamin B2 Nanocrystals with Optical Waveguiding and Photosensitizing Properties for Potential Biomedical Application
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具有光波导和光敏特性的组装维生素 B2 纳米晶体，具有潜在的生物医学应用
DOI：
10.1002/anie.201900124
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发表时间：
2019-05-27
影响因子：
16.6
通讯作者：
Li, Junbai
中科院分区：
文献类型：
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作者：
Fei, Jinbo;Dai, Luru;Li, Junbai
近年来，合成或组装纳米生物材料的研究取得了巨大的成功。其中，具有特殊光学性质的基于生物分子的纳米结构引起了人们的特别关注。在这里，我们证明了组装成纳米棒的维生素b(2)纳米晶体可以通过精确控制获得。令人兴奋的是，这种一维纳米结构不仅具有固有的光波导特性，而且具有敏化氧以产生活性氧的能力。利用这些特性，我们将获得的维生素b(2)纳米棒在远程局部光照下应用于单个肿瘤细胞的体外抗癌光动力治疗。此外，利用肿瘤模型探索维生素b(2)纳米棒用于体内光动力治疗。由于这种生物纳米结构，维生素b(2)及其衍生物的新特性和新功能得到了开发。
Great success has been achieved in recent years in the development of synthetic or assembled nanobiomaterials. Among these, biomolecule-based nanoarchitectures with special optical property are of particular interest. Here, we demonstrate that vitaminB(2) nanocrystals assembled as nanorods can be obtained with precise control. Excitingly, such one-dimensional nanostructures not only exhibit intrinsic optical waveguiding properties but also the ability to sensitize oxygen to produce reactive oxygen species. With these properties, we applied the obtained vitaminB(2) nanorods under remotely localized light illumination into single tumour cells invitro for anticancer photodynamic therapy. Further, vitaminB(2) nanorods were explored for invivo photodynamic therapy by using a tumour model. With such bionanostructures, new features and functions of vitaminB(2) and its derivatives have been developed.