National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer
National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer
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DOI：
10.1016/j.ijrobp.2016.10.001
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发表时间：
2017-01-01
影响因子：
7
通讯作者：
Behera, Madhusmita
中科院分区：
文献类型：
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作者：
Higgins, Kristin A.;O'Connell, Kelli;Behera, Madhusmita
目的：分析国家癌症数据库中质子放射治疗非小细胞肺癌（NSCLC）的预后和预测因素。方法和材料：查询国家癌症数据库，收集2004年至2012年接受胸部放疗的I-IV期非小细胞肺癌患者。采用逻辑回归模型确定质子放射治疗的预测因子。通过Cox比例风险模型和log-rank检验评估单因素和多因素与总生存率的相关性。采用倾向评分匹配方法平衡基线协变量，消除选择偏差。结果：共纳入243822例患者，其中光子放射治疗243474例，质子放射治疗348例。病人居住在邮政编码的地区，收入中位数为
Purpose: To analyze outcomes and predictors associated with proton radiation therapy for non-small cell lung cancer (NSCLC) in the National Cancer Database.Methods and Materials: The National Cancer Database was queried to capture patients with stage I-IV NSCLC treated with thoracic radiation from 2004 to 2012. A logistic regression model was used to determine the predictors for utilization of proton radiation therapy. The univariate and multivariable association with overall survival were assessed by Cox proportional hazards models along with log-rank tests. A propensity score matching method was implemented to balance baseline covariates and eliminate selection bias.Results: A total of 243,822 patients (photon radiation therapy: 243,474; proton radiation therapy: 348) were included in the analysis. Patients in a ZIP code with a median incomeof