Sex differences in genetic and environmental contributions to depression symptoms in South Korean adolescent and young adult twins
Sex differences in genetic and environmental contributions to depression symptoms in South Korean adolescent and young adult twins
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DOI：
10.1375/twin.11.3.306
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发表时间：
2008-06-01
影响因子：
0.9
通讯作者：
Hur, Yoon-Mi
中科院分区：
文献类型：
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作者：
Hur, Yoon-Mi
据报道，患病率估计，症状表现，社会文化风险和抑郁症的保护因素在高加索和东亚人群之间存在差异。但是，尽管如此，由于绝大多数关于抑郁症症状的双胞胎研究都是在高加索人中进行的，因此对东亚人抑郁症症状的遗传和环境影响仍然知之甚少。在本研究中，流行病学研究中心-抑郁量表（CES-D）进行了490对韩国青少年和年轻的成年双胞胎（年龄：13-23岁）的电话采访。在男性中，同卵（MZ）和异卵（DZ）双胞胎的相关性是相似的（0.44对0.41），这表明共享的环境因素在抑郁症症状中的重要性。然而，在女性中，同卵双胞胎的相关性远大于异卵双胞胎的相关性（0.40比0.23），表明遗传影响的重要性。女性CES-D的总表型方差大于男性。方差分量模型证实了遗传和环境对抑郁症状影响程度的性别差异：在全模型中，加性遗传、共享环境和个体特异性环境效应分别为12%（95% CI：0-54%）、32%（95% CI：0-53%）和56%（95% CI：44-70%），以及41%（95% CI：0-52%）、0%（95% CI：0-36%）和59%（95% CI：48-72%）。当CES-D的“文化偏见”项目单独分析时，观察到类似的结果。这些方差分量估计在东亚人的抑郁症状重叠，在高加索人中观察到的。
It has been reported that prevalence estimates, symptom presentation, and sociocultural risk and protective factors for depression differ between Caucasian and East Asian populations. But, nonetheless, as the vast majority of twin studies of depression symptoms have been carried out using Caucasians, genetic and environmental influences on depression symptoms in East Asians remain poorly understood. In the present study, the Center for Epidemiologic Studies - Depression Scale (CES-D) was administered to 490 pairs of South Korean adolescent and young adult twins (ages: 13-23 years) by telephone interview. In males, monozygotic (MZ) and dizygotic (DZ) twin correlations were similar (.44 vs. .41), suggesting the importance of shared environmental factors in depression symptoms. In females, however, MZ twin correlation was much greater than DZ twin correlation (.40 vs. .23), indicating the importance of genetic influences. The total phenotypic variance for the CES-D was greater in females than in males. Variance components model confirmed sex differences in the magnitude of genetic and environmental influences on depression symptoms: Additive genetic, shared environmental, and individual specific environmental effects in the full model were, respectively, 12% (95% CI: 0-54%), 32% (95% CI: 0-53%), and 56% (95% CI: 44-70%) in males, and 41% (95% CI: 0-52%), 0% (95% CI: 0-36%), and 59% (95% CI: 48-72%) in females. Similar results were observed when 'culturally biased' items of the CES-D were separately analyzed. These variance components estimates for depression symptoms in East Asians overlap those observed in Caucasians.