Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas
Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas
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DOI：
10.1136/jcp.2011.089805
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发表时间：
2011-08-01
影响因子：
3.4
通讯作者：
Nilbert, Mef
中科院分区：
文献类型：
--
作者：
Carneiro, Ana;Bendahl, Par-Ola;Nilbert, Mef
研究背景Ezrin是一种细胞骨架蛋白，参与肿瘤的生长和侵袭。目的评价Ezrin在四肢和躯干软组织肉瘤中的预后作用。方法应用免疫组织化学方法检测256例混合性软组织肉瘤中Ezrin的表达。结果在软组织肉瘤中，Ezrin表达升高可预测局部复发(HR=1.8，95%CI1.1~2.8；p=0.007)和局部复发(HR=2.4，95%CI1.4~4.3；p=0.02)。与已建立的预后因素的相关性显示，ezrin与坏死(OR=3.9，p&t；0.0001)和ezrin与生长方式(OR=3.1，p=0.0 3)有很强的相关性。术前评估的可能性使Ezrin成为识别将受益于新辅助治疗的高危肉瘤患者的潜在标记物。
Background Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatricosteosarcoma and rhabdomyosarcoma.Aim To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall.Methods Ezrin expression was evaluated by immunohistochemistry on tissue microarrays from a mixed series of 256 soft tissue sarcomas. The expression patterns were correlated to local recurrence and metastasis as well as to established prognostic factors in soft tissue sarcoma.Results Increased ezrin expression predicted development of metastasis (HR = 1.8, 95% CI 1.1 to 2.8; p = 0.007) and local recurrence, also after adjustment for surgical margin (HR = 2.4, 95% CI 1.4 to 4.3; p = 0.02). Correlations to established prognostic factors showed strong associations between ezrin and necrosis (OR = 3.9, p < 0.0001) and ezrin and growth pattern (OR = 3.1, p = 0.03).Conclusions Ezrin independently predicts development of local recurrences and metastases in soft tissue sarcomas. The possibility of preoperative evaluation makes ezrin a potential marker for identification of high-risk sarcoma patients who would benefit from neoadjuvant therapy.