Alignment of dynamic cardiac PET images for correction of motion
Alignment of dynamic cardiac PET images for correction of motion
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DOI：
10.1109/23.568814
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发表时间：
1997-04-01
影响因子：
1.8
通讯作者：
Coleman, RE
中科院分区：
文献类型：
--
作者：
Turkington, TG;DeGrado, TR;Coleman, RE
开发了一种技术来对准来自动态心脏N-13氨正电子发射断层扫描(PET)的图像，来自这些扫描的图像的不准确对准源于呼吸、心脏在胸腔内的运动和患者的整体运动(特别是在药物应激期间)，来自这些扫描的图像表示从高血池浓度到主要的心肌摄取的变化分布，并且通常是噪声的。在该技术中，模板从较长的较晚帧(5-10分钟)定义，这些模板包括与较晚帧匹配的心肌模板、与以左室血池为主的帧匹配的血池模板，以及修改后的血池模板，减少了右心室活动的影响。相关函数被用作每个三维图像帧和适当模板之间平移的最大化参数，该技术在有心肌缺陷的体模、人体和动物数据上进行了测试，体模数据显示该技术在一个体素(1.7 x 1.7 x 4.2 mm(3))内是可靠的，并且人体数据中明显的运动显著减少，从校正的数据测量的血流值显示出两个特征：更高的值，因为图像的感兴趣区域与图像更匹配，以及更平滑的时间-活动曲线，更好的拟合。
A technique was developed to align images from dynamic cardiac N-13 ammonia positron emission tomography (PET) scans, Inaccurate alignment of images from these scans stems from breathing, motion of the heart within the thorax, and overall motion of the patient (particularly during pharmacologic stress), The images from these scans represent changing distributions, from high blood pool concentrations to predominantly myocardial uptake, and are generally noisy, In this technique, templates are defined from a long, late frame (5-10 min), These templates include a myocardial template, which matches late frames, a blood pool template, which matches frames in which the left ventricle blood pool is dominant, and a modified blood pool template, which reduces the effect of activity in the right ventricle. The correlation function is used as the maximized parameter over shifts between each three-dimensional image frame and the appropriate template, The technique was tested on phantom, human, and animal data with myocardial defects, Phantom data showed the technique to be reliable to within one voxel (1.7 x 1.7 x 4.2 mm(3)), and motion which was apparent in human data was reduced significantly, Blood flow values measured from corrected data showed two traits: higher values, due to better matching regions of interest to images, and better fits, due to smoother time-activity curves.