NON-TRANSFERRIN BOUND IRON AND NEUTROPENIA AFTER CYTOTOXIC CHEMOTHERAPY
NON-TRANSFERRIN BOUND IRON AND NEUTROPENIA AFTER CYTOTOXIC CHEMOTHERAPY
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DOI：
10.1136/jcp.47.4.350
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发表时间：
1994-04-01
影响因子：
3.4
通讯作者：
BAREFORD, D
中科院分区：
文献类型：
--
作者：
HARRISON, P;MARWAH, SS;BAREFORD, D
目的-调查和表征细胞毒性化疗后患者血清中非转铁蛋白结合铁 (NTBI) 的出现，并将其与中性粒细胞减少症的发作和持续时间进行比较。方法-通过博莱霉素测定法对接受强化化疗治疗急性白血病或淋巴瘤的患者进行非转铁蛋白结合铁测定。结果-在 27 个化疗疗程中的 26 个疗程后检测到 NTBI，平均持续 14.5 天。 NTBI 的存在与血清铁结合饱和度相关，但与血清铁蛋白无关。所有化疗疗程后均出现中性粒细胞减少症，平均持续 20.0 天。 NTBI和中性粒细胞减少症在23个化疗疗程后同时发生，平均联合持续时间为9.5天。结论-NTBI在细胞毒化疗后患者的血清中持续存在，通常与患者出现中性粒细胞减少症同时存在。这可能是化疗后发生感染的另一个危险因素。
Aims-To investigate and characterise the appearance of non-transferrin bound iron (NTBI) in the serum of patients after cytotoxic chemotherapy and to compare this with the onset and duration of neutropenia.Method-Non-transferrin bound iron was measured by a bleomycin assay in patients undergoing intensive chemotherapy for treatment of acute leukaemia or lymphoma.Results-NTBI was detected after 26 of 27 courses of chemotherapy and lasted for a mean of 14.5 days. The presence of NTBI correlated with the serum iron binding saturation, but not with serum ferritin. Neutropenia occurred after all courses of chemotherapy and lasted for a mean of 20.0 days. NTBI and neutropenia occurred concurrently after 23 courses of chemotherapy, and had a mean joint duration of 9.5 days.Conclusions-NTBI is consistently present in the serum of patients after cytotoxic chemotherapy, often at the same time as the patient is neutropenic. This may be an additional risk factor for the development of infective episodes after chemotherapy.