A Stereoselective Hydroamination Transform To Access Polysubstituted Indolizidines
A Stereoselective Hydroamination Transform To Access Polysubstituted Indolizidines
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DOI：
10.1021/ja211090n
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发表时间：
2012-02-01
影响因子：
15
通讯作者：
Shenvi, Ryan A.
中科院分区：
文献类型：
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作者：
Pronin, Sergey V.;Tabor, M. Greg;Shenvi, Ryan A.
报道了通过定向硼氢化反应对二烯胺进行立体选择性、分子内、形式氢胺化。在此过程中设置了四个立构中心。用该方法可以从简单的不饱和胺合成天然和非天然的中氮茚生物碱。
Stereoselective, intramolecular, formal hydroamination of dienamines via directed hydroboration is reported. Four stereocenters are set in the process. Natural and unnatural indolizidine alkaloids can be synthesized from simple unsaturated amines using the title process.