Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.
Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.
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DOI：
10.1016/j.ijcard.2016.12.097
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发表时间：
2017-03-01
影响因子：
3.5
通讯作者：
Pasipoularides A
中科院分区：
文献类型：
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作者：
Pasipoularides A
在医学过去的大部分时间里，医生在应对疾病预防和治疗方面所能做的最好的事情是基于普通患者的预期反应。然而，目前，随着人类基因组测序的成本大幅下降，更个性化/更精确的心脏病学和医学方法正在成为可能。因此，我们正在见证一个生物医学突飞猛进的时代，对心血管和其他疾病的遗传基础的理解不断加深，这让人想起文艺复兴时期物理-数学科学和生物学-解剖学-心脏病学的创新复兴，同时也是医学知识、教育和实践的根本性变革和改革的时期。现在即将出现的是一种个性化的、以患者为中心的医疗实践方法，其中包括开发新的基于基因的诊断和预防医学策略，并提供基于药物遗传学的最广泛的个性化治疗。随着时间的推移，随着新的个性化医学方法和程序的采用，基因组和高科技方法的转换无疑将改变心脏病学和整个医学的临床实践。显然，未来的前景远远超过目前的成就，而目前的成就最好被视为一个充满希望的开端。现在至关重要的是，多学科保健提供者必须研究临床采用这一新兴革命性范式的驱动因素和障碍，以加速实现其潜力。所以，我们还没有到达那里，但我们肯定已经在路上了。
For most of Medicine’s past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in general is becoming possible, as the cost of sequencing a human genome has declined substantially. As a result, we are witnessing an era of precipitous advances in biomedicine and bourgeoning understanding of the genetic basis of cardiovascular and other diseases, reminiscent of the resurgence of innovations in physico-mathematical sciences and biology-anatomy-cardiology in the Renaissance, a parallel time of radical change and reformation of medical knowledge, education and practice. Now on the horizon is an individualized, diverse patient-centered, approach to medical practice that encompasses the development of new, gene-based diagnostics and preventive medicine tactics, and offers the broadest range of personalized therapies based on pharmacogenetics. Over time, translation of genomic and high-tech approaches unquestionably will transform clinical practice in cardiology and medicine as a whole, with the adoption of new personalized medicine approaches and procedures. Clearly, future prospects far outweigh present accomplishments, which are best viewed as a promising start. It is now essential for pluridisciplinary health care providers to examine the drivers and barriers to the clinical adoption of this emerging revolutionary paradigm, in order to expedite the realization of its potential. So, we are not there yet, but we are definitely on our way.