The CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombians.
The CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombians.
复制标题
CCR5 delta 32 多态性 (rs333) 与哥伦比亚人的干燥综合征或 1 型糖尿病无关。
DOI：
10.1016/j.clim.2013.05.010
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Scofield,RHal
中科院分区：
文献类型：
--
作者：
Maier-Moore,JacenS;Cañas,CarlosA;Tobón,Gabriel;Arango,Alvaro;Anaya,Juan-Manuel;Scofield,RHal
Sjögren综合征(SS)和1型糖尿病(T1D)是一种慢性进行性自身免疫性疾病，分别影响胰腺朗格汉斯胰岛的外分泌腺或β-细胞。这两种疾病的典型特征都包括产生针对自身抗原的抗体以及器官特异性组织中的T和B细胞渗透[12]。促炎症记忆T细胞和单核细胞向慢性炎症组织的迁移是由Th1相关的趋化因子及其受体驱动的。这包括CCR5，一种参与细胞内信号传递的七跨膜域G蛋白偶联受体(GPCR)[3]。在干燥综合征患者中，受SS影响的炎性Th1细胞、腮腺排泄管和结膜上皮细胞中CCR5的mRNA和受体表达显著上调，表明CCR5在PSS疾病的进展和严重程度中具有重要作用[45]。在1型糖尿病中，活化的表达CCR5的T细胞重新聚集到胰腺或肾脏可以促进肾脏疾病和胰岛素产生的障碍[6]。
Sjögren's syndrome (SS) and Type 1 Diabetes (T1D) are chronic, progressive autoimmune diseases that affect exocrine glands or?-cells in the islets of Langerhans in the pancreas, respectively. Typical features of both diseases include production of antibodies against self-antigens and T and B cell infiltrates in organ-specific tissues [12]. Migration of pro-inflammatory memory T cells and monocytes into chronically inflamed tissues is driven by Th1-related chemokines and their receptors. This includes CCR5, a seven-transmembrane domain G protein-coupled receptor (GPCR) involved in intracellular signaling [3]. In Sjögren's syndrome, mRNA and receptor expression of CCR5 are significantly upregulated in inflammatory Th1 cells, parotid gland excretory ducts and conjunctival epithelium of SS-affected individuals indicating that it has a significant role in the progression and severity of pSS disease [45]. In Type 1 Diabetes, recruitment of activated CCR5-expressing T cells to the pancreas or kidney can promote renal disease and impairment of insulin production [6].