A sex difference in the development of liver tumors in rats fed 3'-methyl-4-dimethylaminoazobenzene or 4'-fluoro-4-dimethylaminoazobenzene.
A sex difference in the development of liver tumors in rats fed 3'-methyl-4-dimethylaminoazobenzene or 4'-fluoro-4-dimethylaminoazobenzene.
复制标题
喂食 3-甲基-4-二甲氨基偶氮苯或 4-氟-4-二甲氨基偶氮苯的大鼠肝脏肿瘤发展存在性别差异。
作者：
H. W. Rumsfeld;W. L. Miller;C. A. Baumann
摘要 1.喂食3'-甲基-4-二甲基氨基偶氮苯的雄性大鼠比雌性更容易患上肝肿瘤。人们在 5 年的时间里定期注意到这一点，并且现在也在对照实验中得到了证明。去势者诱发性肝肿瘤的发生率介于男性和女性之间。 2.4'-氟-4-二甲氨基偶氮苯对雄性大鼠的致癌性似乎也高于雌性大鼠。肿瘤发病率的性别差异并不取决于食物或致癌物质摄入量的差异。 3.肝切片或匀浆在体外破坏DAB、3'-Me-DAB或4'-F-DAB的能力不随性别而变化，除非长期喂食致癌物。
Summary 1.Male rats fed 3′-methyl-4-dimethylaminoazobenzene developed liver tumors more readily than females. This has been noted periodically over a 5-year period and has now also been demonstrated in controlled experiments. The incidence of induced liver tumors in castrates was intermediate between that in males and females. 2.4′-Fluoro-4-dimethylaminoazobenzene also appeared to be more carcinogenic in male rats than in females. The sex differences in tumor incidence did not depend upon differences in the intake of food or of carcinogen. 3.The ability of liver slices or homogenates to destroy DAB, 3′-Me-DAB, or 4′-F-DAB in vitro did not vary with sex unless a carcinogen had been fed for a long period of time.