Expression of malignancy in hybrids between normal and malignant cells
Expression of malignancy in hybrids between normal and malignant cells
复制标题
正常细胞和恶性细胞杂交体中恶性肿瘤的表达
DOI：
10.1002/jcp.1040990302
复制
发表时间：
1979
影响因子：
5.6
通讯作者：
H. Koprowski
中科院分区：
文献类型：
--
作者：
C. Croce;Joan Barrick;A. Linnenbach;H. Koprowski
研究了正常人成纤维细胞、表型正常小鼠成纤维细胞或小鼠腹腔巨噬细胞与HT 1080人二倍体纤维肉瘤细胞之间的体细胞杂交体在裸鼠中形成肿瘤的能力。本研究的结果表明，致瘤行为在人-人和小鼠-人杂交细胞中均表现为显性性状。
Somatic cell hybrids between either normal human fibroblasts, phenotypically normal mouse fibroblasts or mouse peritoneal macrophages and HT1080 human diploid fibrosarcoma cells were studied for their ability to form tumors in nude mice. The results of this study indicate that tumorigenic behavior is expressed as a dominant trait in both human‐human and mouse‐human hybrid cells.