Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral
Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral
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DOI：
10.1039/b719603b
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Seeberger, Peter H.
中科院分区：
文献类型：
--
作者：
Gustafsson, Tomas;Ponten, Fritiof;Seeberger, Peter H.
在微型反应器系统中开发了一种安全、官能团耐受且高通量的三甲基铝介导的酰胺键形成反应版本;制备了利莫那班和依法螺环来说明该方法的实用性。
A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method.