Early-onset periodontitis in Morocco is associated with the highly leukotoxic clone of Acintobacillus actinomycetemcomitans
Early-onset periodontitis in Morocco is associated with the highly leukotoxic clone of Acintobacillus actinomycetemcomitans
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DOI：
10.1177/00220345010800062001
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发表时间：
2001-06-01
影响因子：
7.6
通讯作者：
Kilian, M
中科院分区：
文献类型：
--
作者：
Haubek, D;Ennibi, OK;Kilian, M
从早发性牙周炎(EOP)患者中分离到一个伴生放线杆菌的特殊克隆(JP2)，该克隆具有增加的白毒素产生。这项研究的目的是确定摩洛哥学龄儿童中该克隆携带者的频率及其与EOP的相关性。217份菌斑标本中，131份(60.4%)伴生放线菌培养阳性。这些分离株中共有19株在JP2克隆特有的白毒素启动子区域有530个碱基的缺失。有530bp缺失的伴放线放线菌与EOP有很强的相关性(校正OR=29.4；95%CI=8.3-104.4；p<；0.0005)，而没有缺失的伴放线放线菌与Eop无关联(校正OR=1.30；95%CI=0.5-2.9；p=0.750)。这项研究表明，在人类群体中，高白细胞性JP2克隆的地方性存在可能导致EOP的异常高患病率。
A particular clone (JP2) of Actinobacillus actinomycetemcomitans with increased leukotoxin production has been isolated from individuals with early-onset periodontitis (EOP). The aim of this study was to determine the frequency of carriers of this clone and its association with EOP in Moroccan schoolchildren. Of 217 plaque samples, 131 (60.4%) were culture-positive for A. actinomycetemcomitans. A total of 19 of these isolates had a 530-bp deletion in the leukotoxin promoter region characteristic of the JP2 clone. A strong association between the presence of A. actinomycetemcomitans with the 530-bp deletion and EOP was found (adjusted OR = 29.4; 95% Cl = 8.3 - 104.4; p < 0.0005), while no association could be demonstrated between the presence of A. actinomycetemcomitans without the deletion and EOP (adjusted OR = 1.3; 95% Cl = 0.5 - 2.9; p = 0.750). The study demonstrates that the endemic presence, in a human population, of the highly leukotoxic JP2 clone may result in an unusually high prevalence of EOP.