Glycerol turnover in the nonpregnant and ketotic pregnant sheep.
Glycerol turnover in the nonpregnant and ketotic pregnant sheep.
复制标题
非妊娠羊和酮症妊娠羊的甘油周转率。
DOI：
10.1152/ajplegacy.1968.215.4.865
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
E. N. Bergman
中科院分区：
文献类型：
--
作者：
E. N. Bergman
伯格曼N.未孕绵羊和妊娠绵羊甘油含量的测定。Am. J. Physiol.215（4）：865-873. 1968.将标记甘油静脉输注到三组绵羊中：喂食、禁食和双胎妊娠低血糖和酮症。所有动物游离甘油池的周转时间均较快（15- 18 min）。进食动物的平均甘油周转率为0.25 mmole/hr/kg 314，禁食后增加至0.56 mmole/hr/kg 314。酮病绵羊的甘油周转率大大升高（0 -70-0.96 mmol/hr/kgYj 4），血浆甘油和FFA浓度升高。在额外的实验中研究了去甲肾上腺素、胰岛素和葡萄糖对内源性甘油产生的影响。胰岛素和葡萄糖减少甘油生产和甘油，游离脂肪酸和酮体的血浆浓度在酮症。去甲肾上腺素在未怀孕的绵羊中产生相反的作用。可以得出结论，所有这些代理商可以影响反刍动物脂肪组织中的脂解速率，而不仅仅是酯化率。此外，所有实验的甘油周转率似乎与其血浆浓度成正比。它进一步得出结论，甘油浓度主要是甘油生产的反映，而利用率，反过来，主要取决于甘油浓度。
BERGMAN, E. N. Glycerol furnouer in the nonpregnant and k&tic pregnant sheep. Am. J. Physiol. 215(4): 865-873. 1968.Labeled glycerol was infused intravenously into three groups of sheep: fed, fasted, and twin-pregnant hypoglycemic and ketotic. The turnover time of the free glycerol pool was rapid in all animals (15-l 8 min). Mean glycerol turnover rates were 0.25 mmole/hr per kg3i4 in fed animals and increased to 0.56 mmole/hr per kg314 after fasting. Ketotic sheep had greatly elevated glycerol turnover rates (O-70-0.96 mmole/hr per kgYj4) together with elevated plasma glycerol and FFA concentrations. The effects of norepinephrine, insulin, and glucose on endogenous glycerol production were studied in additional experiments. Insulin and glucose decreased glycerol production and the plasma concentrations of glycerol, FFA, and ketone bodies during ketosis. Norepinephrine produced opposite effects in the nonpregnant sheep. It is concluded that all of these agents can affect the rate of lipolysis in ruminant adipose tissue rather than only the rate of esterification. In addition, the rates of glycerol turnover for all experiments seemed directly proportional to its concentration in plasma. It is further concluded that glycerol concentrations mainly are a reflection of glycerol production and that utilization, in turn, is mainly dependent on glycerol concentration.