Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons.
Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons.
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果蝇的味觉习惯依赖于芜菁甘蓝（腺苷酸环化酶）依赖性的 GABA 能抑制神经元的可塑性。
DOI：
10.1101/lm.026641.112
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发表时间：
2012
影响因子：
2
通讯作者：
Mani Ramaswami
中科院分区：
文献类型：
--
作者：
Pushkar D. Paranjpe;Veronica Rodrigues;Veronica Rodrigues;K. VijayRaghavan;Mani Ramaswami;Mani Ramaswami;Mani Ramaswami
在某些情况下，动物似乎忽视了刺激，而在其他情况下，刺激会引起强烈的反应。这种行为的减弱，使动物能够忽视熟悉的、未经强化的刺激，称为习惯化。尽管这种现象无处不在，但人们普遍对其潜在的神经回路知之甚少。当感觉受体被糖刺激时，饥饿的果蝇表现出鼻子伸展反射(PER)。PER之后通常是喂食。然而，如果糖刺激后不允许进食，PER就不再健壮，动物被认为已经习惯了这种刺激。我们的结果表明，PER习惯化需要依赖腺苷环化酶增强食道下神经节(SOG)GABA能神经元的抑制性输出，该神经元介导PER。谷氨酸脱羧酶(GAD1)表达的神经元合成和释放GABA是必需的，胆碱能神经元上的GABA(A)受体是习惯化所必需的。所提出的抑制增强需要谷氨酸/NMDA受体信号，可能在刺激选择性中发挥作用。我们解释了为什么这些数据为一般模型提供了显着和独立的支持，在该模型中，抑制增强是多个神经系统和物种习惯化的基础。
In some situations, animals seem to ignore stimuli which in other contexts elicit a robust response. This attenuation in behavior, which enables animals to ignore a familiar, unreinforced stimulus, is called habituation. Despite the ubiquity of this phenomenon, it is generally poorly understood in terms of the underlying neural circuitry. Hungry fruit flies show a proboscis extension reflex (PER) when sensory receptors are stimulated by sugars. The PER is usually followed by feeding. However, if feeding is disallowed following sugar stimulation, PER is no longer robust, and the animal is considered to be habituated to this stimulus. Our results suggest that PER habituation requires an adenylate cyclase-dependent enhancement of inhibitory output of GABAergic neurons in the subesophageal ganglion (SOG), which mediates PER. GABA synthesis in and release from glutamic acid decarboxylase (GAD1) expressing neurons is necessary, and GABA(A) receptors on cholinergic neurons are required for PER habituation. The proposed inhibitory potentiation requires glutamate/NMDA-receptor signaling, possibly playing a role in stimulus selectivity. We explain why these data provide significant and independent support for a general model in which inhibitory potentiation underlies habituation in multiple neural systems and species.
影响因子：
2.5
作者：
Pulver, Stefan R.;Pashkovski, Stanislav L.;Griffith, Leslie C.
通讯作者：
Griffith, Leslie C.
由于高级中心而不是局部事件的调节而形成的无脊椎动物逃避反射的习惯。
DOI：
10.1073/pnas.92.8.3362
发表时间：
1995
影响因子：
11.1
作者：
Krasne,FB;Teshiba,TM
通讯作者：
Teshiba,TM
果蝇突变萝卜具有多效性行为效应，并且不会具体影响学习。
DOI：
10.1101/lm.3.5.425
发表时间：
1997
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Mihalek,RM;Jones,CJ;Tully,T
通讯作者：
Tully,T