Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.
Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.
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DOI：
10.1111/acer.13491
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Gizer IR
中科院分区：
文献类型：
--
作者：
Yeung EW;Craggs JG;Gizer IR
Alcohol use disorder (AUD) is highly comorbid with chronic pain (CP). Evidence has suggested that neuroadaptive processes characterized by reward deficit and stress surfeit are involved in the development of AUD and pain chronification. Neurological data suggest that shared genetic architecture associated with the reward and stress systems may contribute to the comorbidity of AUD and CP. This monograph first delineates the prevailing theories of the development of AUD and pain chronification focusing on the reward and stress systems. It then provides a brief summary of relevant neurological findings followed by an evaluation of evidence documented by molecular genetic studies. Candidate gene association studies have provided some initial support for the genetic overlap between AUD and CP, however these results must be interpreted with caution until studies with sufficient statistical power are conducted and replications obtained. Genome-wide association studies have suggested a number of genes (e.g., TBX19, HTR7, and ADRA1A) that are either directly or indirectly related to the reward and stress systems in the AUD and CP literature. Evidence reviewed in this monograph suggests that shared genetic liability underlying the comorbidity between AUD and CP, if present, is likely to be complex. As the advancement in molecular genetic methods continues, future studies may show broader central nervous system involvement in AUD-CP comorbidity.
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影响因子：
--
作者：
Aneiros-Guerrero A;Lendinez AM;Palomares AR;Perez-Nevot B;Aguado L;Mayor-Olea A;Ruiz-Galdon M;Reyes-Engel A
通讯作者：
Reyes-Engel A
影响因子：
30.8
作者：
Bulik-Sullivan B;Finucane HK;Anttila V;Gusev A;Day FR;Loh PR;ReproGen Consortium;Psychiatric Genomics Consortium;Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3;Duncan L;Perry JR;Patterson N;Robinson EB;Daly MJ;Price AL;Neale BM
通讯作者：
Neale BM
影响因子：
30.8
作者：
Anttila, Verneri;Winsvold, Bendik S.;Gormley, Padhraig;Kurth, Tobias;Bettella, Francesco;McMahon, George;Kallela, Mikko;Malik, Rainer;de Vries, Boukje;Terwindt, Gisela;Medland, Sarah E.;Todt, Unda;McArdle, Wendy L.;Quaye, Lydia;Koiranen, Markku;Ikram, M. Arfan;Lehtimaki, Terho;Stam, Anine H.;Ligthart, Lannie;Wedenoja, Juho;Dunham, Ian;Neale, Benjamin M.;Palta, Priit;Hamalainen, Eija;Schuerks, Markus;Rose, Lynda M.;Buring, Julie E.;Ridker, Paul M.;Steinberg, Stacy;Stefansson, Hreinn;Jakobsson, Finnbogi;Lawlor, Debbie A.;Evans, David M.;Ring, Susan M.;Farkkila, Markus;Artto, Ville;Kaunisto, Mari A.;Freilinger, Tobias;Schoenen, Jean;Frants, Rune R.;Pelzer, Nadine;Weller, Claudia M.;Zielman, Ronald;Heath, Andrew C.;Madden, Pamela A. F.;Montgomery, Grant W.;Martin, Nicholas G.;Borck, Guntram;Goebel, Hartmut;Heinze, Axel;Heinze-Kuhn, Katja;Williams, Frances M. K.;Hartikainen, Anna-Liisa;Pouta, Anneli;van den Ende, Joyce;Uitterlinden, Andre G.;Hofman, Albert;Amin, Najaf;Hottenga, Jouke-Jan;Vink, Jacqueline M.;Heikkila, Kauko;Alexander, Michael;Muller-Myhsok, Bertram;Schreiber, Stefan;Meitinger, Thomas;Wichmann, Heinz Erich;Aromaa, Arpo;Eriksson, Johan G.;Traynor, Bryan J.;Trabzuni, Daniah;Rossin, Elizabeth;Lage, Kasper;Jacobs, Suzanne B. R.;Gibbs, J. Raphael;Birney, Ewan;Kaprio, Jaakko;Penninx, Brenda W.;Boomsma, Dorret I.;van Duijn, Cornelia;Raitakari, Olli;Jarvelin, Marjo-Riitta;Zwart, John-Anker;Cherkas, Lynn;Strachan, David P.;Kubisch, Christian;Ferrari, Michel D.;van den Maagdenberg, Arn M. J. M.;Dichgans, Martin;Wessman, Maija;Smith, George Davey;Stefansson, Kari;Daly, Mark J.;Nyholt, Dale R.;Chasman, Daniel I.;Palotie, Aarno
通讯作者：
Palotie, Aarno
影响因子：
2.2
作者：
Cox, Hannah C.;Lea, Rod A.;Bellis, Claire;Carless, Melanie;Dyer, Thomas D.;Curran, Joanne;Charlesworth, Jac;Macgregor, Stuart;Nyholt, Dale;Chasman, Daniel;Ridker, Paul M.;Schuerks, Markus;Blangero, John;Griffiths, Lyn R.
通讯作者：
Griffiths, Lyn R.
DOI：
10.1002/ajmg.b.30091
发表时间：
2004-08-15
影响因子：
2.8
作者：
Covault, J;Gelernter, J;Kranzler, HR
通讯作者：
Kranzler, HR