Eupatilin inhibits adipogenesis through suppression of PPARγ activity in 3T3-L1 cells
Eupatilin inhibits adipogenesis through suppression of PPARγ activity in 3T3-L1 cells
复制标题
Eupatilin通过抑制3 T3-L1细胞中的PPARγ活性抑制脂肪生成
DOI：
10.1016/j.biopha.2018.03.073
复制
发表时间：
2018-07-01
影响因子：
7.5
通讯作者：
Nam, Ju-Ock
中科院分区：
文献类型：
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作者：
Kim, Jin Soo;Lee, Seul Gi;Nam, Ju-Ock
Eupatilin (5,7-dihydroxy-3', 4', 6-trimethoxyflavone) is a flavonoid compound from Artemisia species that possesses beneficial biological activities such as anti-cancer, anti-oxidation, and anti-inflammatory activities. However, an anti-adipogenic effect has not yet been reported. In this study, we found that eupatilin significantly inhibited the adipogenesis of 3T3-L1 adipocytes. Eupatilin decreased intracellular lipid accumulation and suppressed the expression level of key adipogenic regulators in 3T3-L1 adipocytes, including peroxisome proliferator-activated receptor gamma (PPAR.) and CCAAT-enhancer-binding protein alpha (C/EBPa), in a concentration-dependent manner. These results show that eupatilin significantly inhibits 3T3-L1 cell differentiation and suggest that it has potential as a novel anti-obesity therapy.
