Phospholipid molecular species in human umbilical artery and vein endothelial cells.
Phospholipid molecular species in human umbilical artery and vein endothelial cells.
复制标题
人脐动脉和静脉内皮细胞中的磷脂分子种类。
DOI：
10.1016/s0021-9258(18)32394-9
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发表时间：
1990
影响因子：
6.5
通讯作者：
Makato Kite
中科院分区：
文献类型：
--
作者：
Hitoshi Takamura;Hisanori Kasai;Hitoshi Arita;Makato Kite
定量测定了人脐动脉和脐静脉内皮细胞中几种磷脂类和亚类的分子种类。两种类型的内皮细胞的磷脂类组成相似，而它们的磷脂亚类和分子种类组成显着不同。动脉内皮细胞中磷脂酰胆碱和磷脂酰乙醇胺的两个醚亚类的含量高于静脉内皮细胞。磷脂酰胆碱（血小板活化因子的前体）中烷基酰基亚类的相对含量在动脉内皮细胞中比在静脉内皮细胞中高约3倍。在动脉内皮细胞中，花生四烯酸在烯基酰基磷脂酰乙醇胺中含量最高，其次是二酰基磷脂酰胆碱、二酰基磷脂酰乙醇胺和磷脂酰肌醇。在静脉内皮细胞中，花生四烯酸在磷脂酰肌醇中含量最高，其次是二酰基磷脂酰乙醇胺、二酰基磷脂酰胆碱和烯酰基磷脂酰乙醇胺。在所有磷脂类和亚类中，动脉内皮细胞比静脉内皮细胞具有更高量的含有花生四烯酸的分子种类。这些差异被认为反映了动脉和静脉内皮细胞的功能差异。
Molecular species of several phospholipid classes and subclasses were quantitatively determined in human umbilical artery and vein endothelial cells. Both types of endothelial cells were similar in phospholipid class composition, whereas they were markedly different in phospholipid subclass and molecular species composition. The amounts of two ether subclasses in phosphatidylcholine and phosphatidylethanolamine were higher in artery endothelial cells than those in vein endothelial cells. The relative content of alkylacyl subclass in phosphatidylcholine, a precursor of platelet-activating factor, was about three times higher in artery endothelial cells than in vein endothelial cells. In artery endothelial cells, arachidonic acid was in highest amounts in alkenylacyl phosphatidylethanolamine, followed by diacyl phosphatidylcholine, diacyl phosphatidylethanolamine, and phosphatidylinositol. In the vein endothelial cells, arachidonic acid was highest in phosphatidylinositol, followed by diacyl phosphatidylethanolamine, diacyl phosphatidylcholine, and alkenylacyl phosphatidylethanolamine. Artery endothelial cells had higher amounts of molecular species containing arachidonic acid than vein endothelial cells in all phospholipid classes and subclasses. These differences are thought to reflect the functional differences of artery and vein endothelial cells.
培养的人脐静脉内皮细胞的磷脂类和亚类中类二十烷酸前体脂肪酸的周转。
DOI：
10.1042/bj2580427
发表时间：
1989
期刊：
The Biochemical journal
影响因子：
--
作者：
Takayama,H;Kroll,MH;GimbroneJr,MA;Schafer,AI
通讯作者：
Schafer,AI
类二十烷酸前体脂肪酸优先掺入人脐静脉内皮细胞磷脂中。
DOI：
10.1016/0005-2760(87)90054-3
发表时间：
1987
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Takayama,H;GimbroneJr,MA;Schafer,AI
通讯作者：
Schafer,AI