Prospective study of oral contraceptive use and risk of breast cancer in women.
Prospective study of oral contraceptive use and risk of breast cancer in women.
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女性口服避孕药使用与乳腺癌风险的前瞻性研究。
DOI：
10.1093/jnci/81.17.1313
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Speizer,FE
中科院分区：
文献类型：
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作者：
Romieu,I;Willett,WC;Colditz,GA;Stampfer,MJ;Rosner,B;Hennekens,CH;Speizer,FE
1976年，118，273名年龄在30-55岁之间、没有癌症病史的女护士完成了一份关于可能的危险因素的问卷。到1986年，经过1,137,415人年的随访，我们记录了1,799例新诊断的乳腺癌病例。与不使用口服避孕药者乳腺癌的危险度相比，多因素相对危险度为1.07（95%置信区间，0.97-1.19）对于所有用户，1.06（95%置信区间，0.96-1.18）对于既往使用者，1.53（95%置信区间，1.06-2.19）为目前的用户，妇女谁使用口服避孕药长达2年前诊断乳腺癌。我们的结论是，过去口服避孕药的总体使用与乳腺癌风险的大幅增加无关。尽管我们没有发现在第一次怀孕前使用口服避孕药的女性患乳腺癌的风险增加，但在生育早期长期使用口服避孕药的女性数量太少，无法得出关于该亚组风险的确切结论。[J Natl Cancer Inst 81：1313-1321，1989]
In 1976, 118,273 female nurses 30–55 years of age with no history of cancer completed a questionnaire regarding possible risk factors. By 1986, after 1,137,415 person-years of follow-up, we had documented 1,799 newly diagnosed cases of breast cancer. Compared with the risk of breast cancer for nonusers of oral contraceptives, the multivariate relative risks were 1.07 (95% confidence interval, 0.97–1.19) for all users, 1.06 (95% confidence interval, 0.96–1.18) for past users, and 1.53 (95% confidence interval, 1.06–2.19) for current users—women who used oral contraceptives up to 2 years before diagnosis of breast cancer. We conclude that overall past use of oral contraceptives is not associated with a substantial increase in the risk of breast cancer. Although we did not find women who used oral contraceptives before the first pregnancy to have an increased risk of breast cancer, the number of women who used oral contraceptives for a long duration in early reproductive life was too small to permit firm conclusions regarding the risk in this subgroup. [J Natl Cancer Inst 81:1313–1321, 1989]