Asthma and allergy to house-dust mites in populations living in high altitudes.
Asthma and allergy to house-dust mites in populations living in high altitudes.
复制标题
居住在高海拔地区的人群患有哮喘和对屋尘螨过敏。
作者：
Denis Charpin;Jean;A. Lanteaume;Hassan Razzouk;Daniel Vervloet;Mondher Toumi;Fadel Faraj;Jacques Charpin
生活在屋尘螨不常见的高海拔地区的受试者是否表现出较低的哮喘和对屋尘螨过敏的患病率？为了回答这个问题，我们比较了两个城镇的哮喘患病率和对室内尘螨的皮肤反应，这两个城镇的环境截然不同：位于海滨的马赛和海拔1350米的布里安松。研究人群包括马赛的4,008人和布里扬松的1,055人的随机样本。所有受试者均接受家庭问卷调查，并对患者和无症状受试者进行皮肤点刺试验评价。马赛的哮喘累积患病率为4.1%，布里扬松为2.4%，差异显着（p = 0.01）。在无症状受试者中，屋尘螨皮试阳性的患病率在马赛为27.5%，在布里安松为10.2%（p <0.001）。这项研究支持了这一假设，即暴露于环境因素可能对发展过敏性疾病有重大影响。
Do subjects living in high altitude where house-dust mites are known to be uncommon exhibit a lower prevalence of asthma and allergy to house-dust mites? To answer this question, we compared the prevalence rates of asthma and skin reactions to house-dust mites in two towns with contrasted environments: Marseille, located on the seashore, and Briançon, 1350 m in altitude. The study population consisted of a random sample of 4,008 people in Marseille and 1,055 people in Briançon. All subjects received a home questionnaire, and a sample of patients and asymptomatic subjects had a skin-prick test evaluation. The cumulative prevalence of asthma was equal to 4.1 percent in Marseille and 2.4 percent in Briançon, a difference which was significant (p = 0.01). The prevalence of positive skin tests to housedust mites in asymptomatic subjects was equal to 27.5 percent in Marseille and 10.2 percent in Briançon (p less than 0.001). This study supports the hypothesis that exposure to environmental factors may have a major influence on developing allergic diseases.