Amine-Induced Michael/Conia-Ene Cascade Reaction: Application to a Formal Synthesis of (±)-Clavukerin A
Amine-Induced Michael/Conia-Ene Cascade Reaction: Application to a Formal Synthesis of (±)-Clavukerin A
复制标题
胺诱导的 Michael/Conia-Ene 级联反应：在 (±)-Clavukerin A 正式合成中的应用
DOI：
10.1021/ol902567e
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发表时间：
2010-02-05
期刊：
影响因子：
5.2
通讯作者：
Lee, Chi-Sing
中科院分区：
文献类型：
--
作者：
Li, Wei;Liu, Xiaozu;Lee, Chi-Sing
以简单的无环β-酮酸酯为底物，一锅法合成6，6-和5，7-双环稠合碳环，并成功地应用于(+/-)-Clavukerin A的合成。
An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic beta-ketoesters as the substrates in one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (+/-)-Clavukerin A.