Development of Calcium Phosphate Cement Containing Carboxymethyl-Chitin and Succinic Acid for Bone Substitute.
Development of Calcium Phosphate Cement Containing Carboxymethyl-Chitin and Succinic Acid for Bone Substitute.
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含羧甲基甲壳素和琥珀酸的骨替代品磷酸钙水泥的开发。
DOI：
10.2186/jjps.44.9
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Masanori Nakasu
中科院分区：
文献类型：
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作者：
A. Yokoyama;Satoru Yamamoto;Hiromi Komatsubara;A. Takeishi;T. Kawasaki;T. Kohgo;Masanori Nakasu
本研究的目的是研制一种新型的磷酸钙骨水泥作为骨替代品。骨水泥由液体和粉末成分组成。粉末成分由α-磷酸三钙、磷酸四钙和磷酸二钙二水合物组成。使用两种类型的液体组分;一种含有羧甲基甲壳素、琥珀酸和磷酸氢二钠溶液（SAcement），另一种含有蒸馏水（DW水泥）。研究两种骨水泥的力学性能和生物相容性。将粉末和液体成分结合后，发现SA水泥形成了“油灰状”稠度，可以模制成任何所需的形状。然而，DW骨水泥无法成型。SA骨水泥的抗压强度高于DW骨水泥。术后1周组织学检查显示，植入DW骨水泥的大鼠皮下组织周围炎症反应较SA骨水泥稍轻。在4周时，移植到骨上的SA骨水泥与骨的结合与DW骨水泥一样有效。结果表明，这种在液体成分中使用琥珀酸和羧甲基甲壳素的新型磷酸钙骨水泥适合作为骨替代品。
The purpose of this study was to develop a new calcium phosphate cement as a bonesubstitute. The cement consisted of liquid and powder components. The powder component consisted of α-tricalcium phosphate, tetracalcium phosphate and dicalcium phosphate dihydrate. Two types of liquid component were used; one contained carboxymethyl-chitin, succinic acid and disodium hydrogen phosphate solution (SAcement), and the other distilled water (DW cement). The mechanical properties and biocompatibility of the two cements were investigated. After combining the powder and liquid components, the SA cement was found to develop a “putty-like” consistency that could be molded into any desired shape. However, the DW cement could not be molded. The compressive strength was higher in the SA cement than in the DW cement. Histological examination showed that inflammation around the DW cement grafted on the subcutaneous tissue in rats was a little less than that around the SA cement at 1 week after grafting. At 4 weeks, the SA cement grafted on the bone had bound to the bone as efficiently as the DW cement. The results suggested that this new calcium phosphate cement using succinic acid and carboxymethyl-chitin in the liquid component is suitable as a bone substitute.