Physicochemical Properties and Antimicrobial Efficacy of Carvacrol Nanoemulsions Formed by Spontaneous Emulsification
Physicochemical Properties and Antimicrobial Efficacy of Carvacrol Nanoemulsions Formed by Spontaneous Emulsification
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自发乳化香芹酚纳米乳的理化性质及抗菌功效
DOI：
10.1021/jf402147p
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发表时间：
2013-09-18
影响因子：
6.1
通讯作者：
McClements, David Julian
中科院分区：
文献类型：
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作者：
Chang, Yuhua;McLandsborough, Lynne;McClements, David Julian
介绍了一种从精油中制备物理稳定的抗菌纳米乳剂的简单、经济有效的方法(自发乳化)。这些纳米乳液(总油相质量分数为10wt%)是由精油(香芹醇)、载体油(中链甘油三酯，MCT)和非离子表面活性剂(吐温)的混合物在连续搅拌下滴定到水溶液中形成的。油相组成(香芹酚与MCT的质量比)对初始液滴直径有重要影响，在2.5wt%香芹酚和7.5wt%MCT时形成最小的液滴(d约为55 nm)。表面活性剂类型对平均液滴直径也有显著影响，吐温80提供食品级非离子表面活性剂(吐温20、40、60、80和85)中最小的液滴(d约为55 nm)。液滴大小也减小(从>；5000降至
A simple cost-effective method (spontaneous emulsification) for fabricating physically stable antimicrobial nanoemulsions from essential oils is described. These nanoemulsions (10 wt % total oil phase) were formed by titration of a mixture of essential oil (carvacrol), carrier oil (medium chain triglyceride, MCT), and nonionic surfactant (Tween) into an aqueous solution with continuous stirring. Oil phase composition (carvacrol-to-MCT mass ratio) had a major impact on initial droplet diameter, with the smallest droplets (d approximate to 55 nm) being formed at 2.5 wt % carvacrol and 7.5 wt % MCT. Surfactant type also had an appreciable impact on mean droplet diameter, with Tween 80 giving the smallest droplets (d approximate to 55 nm) from a group of food-grade nonionic surfactants (Tween 20, 40, 60, 80, and 85). The droplet size also decreased (from >5000 to