Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease.
Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease.
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DOI：
10.1186/s12944-016-0321-5
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发表时间：
2016-09-17
影响因子：
4.5
通讯作者：
Dehn CA
中科院分区：
文献类型：
--
作者：
Paglialunga S;Dehn CA
非酒精性脂肪性肝病（NAFLD）被认为是下一个全球流行病。肝脏新生脂肪生成（DNL），从非脂质来源合成新的脂肪酸，被认为在NAFLD的发展中起着关键作用。虽然目前没有NAFLD特异性治疗剂，但旨在减少肝脏脂肪增生的药物可能被证明是治疗和管理这种疾病的有力盟友。以NAFLD为重点，本文综述了目前从临床角度检查DNL的技术，并介绍了三种常用检测方法的优点和局限性;稳定标记同位素示踪研究，脂肪酸指数和间接量热法作为肝DNL的非侵入性措施。最后，DNL评估在NAFLD/NASH的药物和营养治疗中的应用进行了总结。在临床研究环境中，DNL的测量是开发抗NAFLD治疗的重要标志物。
Non-alcoholic fatty liver disease (NAFLD) is heralded as the next big global epidemic. Hepatic de novo lipogenesis (DNL), the synthesis of new fatty acids from non-lipid sources, is thought to play a pivotal role in the development of NAFLD. While there is currently no NAFLD-specific therapeutic agent available, pharmaceutical drugs aimed at reducing hepatic fat accretion may prove to be a powerful ally in the treatment and management of this disease. With a focus on NAFLD, the present review summarizes current techniques examining DNL from a clinical perspective, and describes the merits and limitations of three commonly used assays; stable-label isotope tracer studies, fatty acid indexes and indirect calorimetry as non-invasive measures of hepatic DNL. Finally, the application of DNL assessments in the pharmacological and nutraceutical treatment of NAFLD/NASH is summarized. In a clinical research setting, measures of DNL are an important marker in the development of anti-NAFLD treatments.
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