Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats
Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats
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DOI：
10.1016/j.pbb.2008.05.013
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发表时间：
2008-10-01
影响因子：
3.6
通讯作者：
Devaud, Leslie L.
中科院分区：
文献类型：
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作者：
Koirala, Bikul;Alele, Paul E.;Devaud, Leslie L.
我们之前报道了乙醇戒断 (EW) 恢复以及 EW 期间对 GABA(A) 受体调节剂敏感性的显着性别差异。本研究的目的是通过比较两种不同的行为，确定激素状态是否会调节 EW 动物对急性乙醇挑战的行为反应。最初的一组实验探讨了 EW 期间在停药第 1 天或第 3 个粘土时急性乙醇注射对运动不协调的影响。 EW 男性，但不是女性。与对照组相比，大鼠表现出协调性下降，并持续 3 天。雌性大鼠在 EW 第 1 天表现出对急性乙醇攻击的运动不协调行为的耐受性，而 EW 雄性大鼠在第 3 天时耐受性更为明显。相比之下，EW 动物通常对乙醇的抗惊厥作用保持敏感，无论激素状态如何。而电子波本身并没有显着改变癫痫发作潜伏期。持续时间或严重程度，它增加了癫痫引起的死亡率，尤其是在 3 天 EW 时。有一些证据表明，在最低剂量（0.62 g/kg）下，急性乙醇激发的抗惊厥作用具有耐受性，该剂量因性别条件和 EW 时间而异。所有性别条件都对所研究的两个较高剂量的乙醇激发的抗惊厥作用表现出显着的敏感性。总体而言，去卵巢的雌性对急性乙醇给药表现出最大的反应。这些发现提供了 EW 期间行为反应差异的额外证据，并表明多种神经适应调节了 EW 期间对乙醇的各种反应，其中激素状态的影响较小。 (C) 2008 Elsevier Inc. 保留所有权利。
We previously reported significant sex differences in ethanol withdrawal (EW) recovery as well as in sensitivity to GABA(A) receptor modulators during EW. The aim of the present study was to determine if hormonal status moderated behavioral responses to an acute ethanol challenge in EW animals comparing two different behaviors. An initial set of experiments explored motor-incoordinating effects of the acute ethanol injection during EW at either I day or 3 clays of withdrawal. EW male, but not female. rats showed a decrease in coordination compared to controls that persisted through 3 days EW. Female rats displayed tolerance to the motor-incoordinating actions of the acute ethanol challenge at I day EW whereas tolerance was more evident in EW male rats at 3 days. In contrast, EW animals generally remained responsive to the anticonvulsant actions of ethanol, irrespective of hormonal status. While EW by itself did not significantly alter seizure latency. duration or severity, it increased seizure-induced mortality especially at 3 days EW. There was some evidence of tolerance to the anticonvulsant effect of the acute ethanol challenge at the lowest dose employed (0.62 g/kg), which varied by sex condition and time of EW. All sex conditions displayed marked sensitivity to the anticonvulsant effects of the ethanol challenge at the two higher doses studied. Overall, ovariectornized females showed the greatest response to the acute ethanol administration. These findings provide additional evidence of a divergence in behavioral responses during EW and suggest that multiple neuroadaptations moderate various responses to ethanol during EW, with minor contributions of hormonal status. (C) 2008 Elsevier Inc. All rights reserved.