Findings from a 1000-patient Internet-based survey assessing the impact of morning symptoms on individuals with allergic rhinitis
Findings from a 1000-patient Internet-based survey assessing the impact of morning symptoms on individuals with allergic rhinitis
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DOI：
10.1016/j.clinthera.2007.02.007
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发表时间：
2007-02-01
影响因子：
3.2
通讯作者：
Long, Aidan A.
中科院分区：
文献类型：
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作者：
Long, Aidan A.
背景：虽然过敏性鼻炎症状的严重程度可能取决于接触触发过敏原的程度，但人们也注意到症状的严重程度在一天的过程中是不同的。目的：本研究的目的是调查早上症状对过敏性鼻炎患者的影响(对行为和/或感觉的影响)，并确定他们对过敏治疗有效性的看法。方法：2005年1月，基于16项问卷对美国18岁经医生诊断为过敏性鼻炎的成年人进行了在线访谈。参与者是从罗珀公共事务和媒体美国国家在线小组招募的。调查样本经过平衡，以反映美国人口普查司、种族、性别和是否有儿童居住在家中。结果：符合所有纳入/排除标准的前1000名受访者(性别，女性550[55%]；年龄，年龄=55岁，378[38%]；种族，白人，883[88%])被纳入研究结果。参与者的地区分布没有显著差异：南部(34%)、中西部(25%)、西部(22%)和东北部(19%)。大多数样本(83%)报告经历了上午的过敏性鼻炎症状；49%的人报告说他们的症状在早上最严重。醒来时最常见的症状是鼻塞，85%的人报告说他们第一次醒来时有症状。在那些有觉醒症状的人中，大多数人报告说，这些症状影响了他们的感觉(96%)或行为(87%)。在觉醒时出现症状的受访者中，大多数人报告称，他们的症状对一天中的其余时间有“一定”或“很大”的影响(分别为51%和24%)。在使用过敏药物的受访者中，33%的人报告说，其有效性在下一次剂量之前大部分或所有时间都会消失。大多数受访者认为，过敏药物在下一次服药前保持有效性(68%)，全天缓解并持续到第二天早上(62%)，并使他们醒来时症状得到控制(63%)是非常重要的。结论：根据这项基于互联网的大型调查结果，过敏性鼻炎早上的症状对个人的情绪和日常活动中断都有负面影响。据报道，用于治疗过敏性鼻炎的药物并不总是在两次剂量之间的整个时间间隔内有效。这表明，在考虑变应性鼻炎的治疗方案时，选择在24小时内提供持续有效的药物可能是重要的。
Background: Although the severity of allergic rhinitis symptoms might depend on the degree of exposure to the triggering allergen, it has also been noted that symptom severity varies over the course of the day.Objectives: The alms of this study were to investigate the reported impact (influence on behavior and/or feelings) of morning symptoms on individuals with allergic rhinitis and determine their perception of the effectiveness of allergy treatment.Methods: In January 2005, online interviews based on a 16-item questionnaire were presented to adults (aged >= 18 years) with physician-diagnosed allergic rhinitis in the United States. Participants were recruited from the Roper Public Affairs and Media US national online panel. The survey sample was balanced to reflect the US population by Census Division, ethnicity, sex, and presence of children living at home. Data were weighted by sex (65% female, 35% male) based on previous research of the adult population suffering from allergies.Results: The first 1000 respondents (sex, female, 550 [55%]; age, >= 55 years, 378 [38%]; race, white, 883 [88%]) that met all inclusion/exclusion criteria were included in the study results. There was no significant difference in the regional distribution of participants: South (34%), Midwest (25%), West (22%), and Northeast (19%). The majority of the sample (83%) reported experiencing morning symptoms of allergic rhinitis; 49% reported that their symptoms were most severe during the morning hours. The most common symptom on awakening was nasal congestion, reported by 85% of those with symptoms when they first woke up. Of those with symptoms on awakening, the majority reported that these affected their feelings (96%) or behavior (87%). Among respondents who experienced symptoms on awakening, the majority reported that their symptoms affected the rest of their day "somewhat" or "a great deal" (51% and 24%, respectively). Of those respondents using allergy medication, 33% reported that its effectiveness wore off before the next dose most or all of the time. A majority of respondents reported feeling that it was very important for an allergy medication to maintain effectiveness until the next dose (68%), provide relief all day and into the next morning (62%), and enable them to wake up with their symptoms under control (63%).Conclusions: Based on the results from this large Internet-based survey, the morning symptoms of allergic rhinitis have a negative impact on individuals, both emotionally and in terms of disruption of daily activities. Medication used for treating allergic rhinitis was reported as not always effective for the whole time interval between doses. This suggests that it might be important, when considering management options in allergic rhinitis, to select medications that offer sustained effectiveness throughout the 24-hour period.