Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.
Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.
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DOI：
10.1016/j.mad.2018.08.001
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发表时间：
2019-01
影响因子：
5.3
通讯作者：
Mack HID
中科院分区：
文献类型：
--
作者：
Denzel MS;Lapierre LR;Mack HID
衰老研究中的关键发现得益于模式生物的使用。秀丽隐杆线虫是一种寿命较短的线虫，已成为研究衰老的成熟体系。这种后生动物的实用性以及与之相关的强大基因操作手段，彻底改变了我们理解生物体衰老过程的能力。在发现daf - 2基因作为寿命的遗传调节因子这一成果发表25年后，秀丽隐杆线虫在探索衰老过程的研究中依旧至关重要。线虫衰老研究已证实，其在识别转录调节因子、小分子信号、细胞机制、与抗逆性和长寿相关的表观遗传修饰以及延长寿命的化合物等方面很有帮助。在此，我们回顾了利用这种神奇的小蠕虫在衰老研究中取得的最新发现及部分选定主题。
Key discoveries in aging research have been made possible with the use of model organisms. Caenorhabditis elegans is a short-lived nematode that has become a well-established system to study aging. The practicality and powerful genetic manipulations associated with this metazoan have revolutionized our ability to understand how organisms age. 25 years after the publication of the discovery of the daf-2 gene as a genetic modifier of lifespan, C. elegans remains as relevant as ever in the quest to understand the process of aging. Nematode aging research has proven useful in identifying transcriptional regulators, small molecule signals, cellular mechanisms, epigenetic modifications associated with stress resistance and longevity, and lifespan-extending compounds. Here, we review recent discoveries and selected topics that have emerged in aging research using this incredible little worm.
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影响因子：
64.8
作者：
Agger, Karl;Cloos, Paul A. C.;Helin, Kristian
通讯作者：
Helin, Kristian
影响因子：
7.8
作者：
Ayyadevara, Srinivas;Balasubramaniam, Meenakshisundaram;Reis, Robert Shmookler
通讯作者：
Reis, Robert Shmookler
影响因子：
29
作者：
Alam H;Williams TW;Dumas KJ;Guo C;Yoshina S;Mitani S;Hu PJ
通讯作者：
Hu PJ
DOI：
10.1186/2046-2395-3-5
发表时间：
2014
期刊：
Longevity & healthspan
影响因子：
--
作者：
Bansal A;Kwon ES;Conte D Jr;Liu H;Gilchrist MJ;MacNeil LT;Tissenbaum HA
通讯作者：
Tissenbaum HA
影响因子：
4.6
作者：
Berber, Slavica;Wood, Mallory;Nicholas, Hannah R.
通讯作者：
Nicholas, Hannah R.