Serum BPI as a novel biomarker in asthma
Serum BPI as a novel biomarker in asthma
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DOI：
10.1186/s13223-020-00450-0
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发表时间：
2020-06-18
影响因子：
2.7
通讯作者：
Chen, Qiu
中科院分区：
文献类型：
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作者：
Chen, Xingyuan;Chen, Qiu
背景中性粒细胞、嗜酸性粒细胞和炎性细胞参与哮喘炎症反应。抗杀菌/通透性增加蛋白(BPI)由中性粒细胞、外周血单核细胞或上皮细胞产生，可中和脂多糖活性，增强吞噬调节功能。本研究旨在探讨BPI在哮喘患者中的临床意义。方法受试者包括18例哮喘对照组、39例非控制哮喘组和35例健康对照组。比较两组患者的临床特征(年龄、性别、过敏史、体重指数(BMI)、吸烟史)、临床指标[全血计数、1秒用力呼气量占预计值百分比(FEV1%)、IgE水平、超敏C反应蛋白(hs-CRP)、呼气一氧化氮分数(FeNO)]和血清BPI水平。然后我们评估了BPI、临床特征和临床指标之间的相关性。最后进行线性回归分析，排除其他因素的影响，找出影响BPI的独立因素。结果与健康对照组(6.0 0±2.5 8 ng/m L)相比，哮喘控制组(12.83+/-6.0 4 ng/m L)和非控制哮喘组(18.10+/-13.48 ng/m L)血清BPI水平分别升高了2倍和3倍(p<；0.001)。我们进一步发现，血清BPI水平与hs-CRP值呈正相关(p=0.002)。BPI、年龄、性别、BMI、变态反应、血嗜酸粒细胞、血中性粒细胞、IgE、FeNO或FEV1%与预测无关。结论哮喘患者BPI水平升高，且与hs-CRP呈正相关。BPI作为一种潜在的哮喘生物标志物仍需进一步研究。
Background Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithelial cells, can neutralize lipopolysaccharide activity and enhance phagocytosis regulation function. This study aimed to assess the clinical significance of BPI in asthmatic patients. Methods We recruited 18 controlled asthma, 39 uncontrolled asthma and 35 healthy controls individuals. Clinical characteristics (age, gender, allergy history, body mass index (BMI) and smoking history), clinical indicators [whole blood count, forced expiratory volume in one second as percentage of predicted volume (FEV1% predicted), IgE level, high sensitivity C-reactive protein (hs-CRP) and fractional expiratory nitric oxide (FeNO)] and serum BPI levels were measured to compare among each group. We then evaluated the correlation between BPI, clinical characteristics and clinical indicators. Finally, linear regression analysis was performed to exclude the influence of other factors and to find the independent influencing factors of BPI. Results Our results showed that the serum BPI levels increased by twofold in the controlled asthma group (12.83 +/- 6.04 ng/mL) and threefold in the uncontrolled asthma group (18.10 +/- 13.48 ng/mL), compared to the healthy control group (6.00 +/- 2.58 ng/mL) (p < 0.001). We further found that serum BPI levels were positively correlated with the hs-CRP (p = 0.002). There was no significant association among BPI, age, gender, BMI, allergy, blood eosinophils, blood neutrophils, IgE, FeNO or FEV1% predicted. Conclusion BPI levels were increased in asthma and positively correlated with hs-CRP. BPI as a potential asthma biomarker that still needs further research.