Towards understanding the evolution of the human commensal yeast Candida albicans
Towards understanding the evolution of the human commensal yeast Candida albicans
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DOI：
10.1099/13500872-145-5-1137
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发表时间：
1999-05-01
期刊：
影响因子：
--
通讯作者：
Arnold, J
中科院分区：
文献类型：
--
作者：
Lott, TJ;Holloway, BP;Arnold, J
等位基因频率和一个双态性位点和三个非连锁多态性位点的关系已确定为114无关的分离株的白色念珠菌，包括14个实验室参考菌株和50株，从两个地理区域。虽然没有地理分区的迹象，有显着的相关性，特定的等位基因对位点之间，几乎没有证据表明，任何等位基因在Hardy-Weinberg平衡。这为以下概念提供了额外的支持：该物种遗传遗传的主要模式是克隆，其他细胞内遗传事件在基因组多样性的创造中发挥较小的作用。通过推断这一点和其他已知的属性密切相关的念珠菌属物种，如IS 1和ITS 2（内部转录间隔区2）的rDNA顺反子区域的序列分析，推断的同源性表明，许多经常分离的菌株进化最近的起源。这一发现将是在了解致病性和耐药性的背景下，在这种人类酵母菌的兴趣。
Allelic frequencies and relationships for one dimorphic locus and three unlinked polymorphic loci have been determined for 114 unrelated isolates of Candida albicans, including 14 laboratory reference strains and 50 strains from each of two geographic regions. Although there was no indication of geographical partitioning, there were significant correlations for specific allelic pairs among loci and little evidence that any alleles were in Hardy-Weinberg equilibrium. This gives additional support for the concept that the primary mode of genetic inheritance in this species is clonal, with other intracellular genetic events playing a lesser role in the creation of genomic diversity. Through inference of this and other known attributes of closely related Candida species, such as sequence analysis of IS1 and the ITS2 (internal transcribed spacer 2) region of the rDNA cistron, the deduced phylogeny suggests an evolutionarily recent origin for many frequently isolated strains. This finding will be of interest in the context of understanding pathogenicity and drug resistance in this human commensal yeast.