PREDICTION OF MECHANICAL-PROPERTIES OF HUMAN ATHEROSCLEROTIC TISSUE BY HIGH-FREQUENCY INTRAVASCULAR ULTRASOUND IMAGING - AN INVITRO STUDY
PREDICTION OF MECHANICAL-PROPERTIES OF HUMAN ATHEROSCLEROTIC TISSUE BY HIGH-FREQUENCY INTRAVASCULAR ULTRASOUND IMAGING - AN INVITRO STUDY
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DOI：
10.1161/01.atv.12.1.1
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
PANDIAN, N
中科院分区：
文献类型：
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作者：
LEE, RT;RICHARDSON, SG;PANDIAN, N
血管内超声可能有助于研究不同形态的动脉粥样硬化病变的自然史并指导介入策略。本研究旨在检验血管内超声显示的组织外观与动脉粥样硬化成分的生物力学特性相关的假设。在尸检时从 22 名患者的腹主动脉中获取了 43 个动脉粥样硬化帽，并用超灵敏伺服控制光谱仪进行了研究。通过测量由 30 毫米汞柱增加到 90 毫米汞柱的压应力水平引起的静态应变，确定了单轴无侧限压缩刚度（应力与应变之比）。机械测试后，使用 6F、20 MHz 血管内超声换能器对标本进行成像，并由不了解机械测量结果的研究人员解释图像。根据血管内超声外观，标本被分为非纤维性 (n = 14)、纤维性 (n = 18) 或钙化性 (n = 11)。非纤维性、纤维性和钙化超声类别的静态刚度分别为 41.2 +/- 18.8 kPa、81.7 +/- 33.2 kPa 和 354.5 +/- 245.4 kPa（方差分析 p = 0.0002）。非纤维类、纤维类和钙化类达到静态平衡（蠕变时间）的时间分别为 79.6 +/- 26.5 分钟、50.2 +/- 20.0 分钟和 19.4 +/- 8.1 分钟（p = 0.0007）。当注意到钙沉积时，血管内超声表现与生物力学行为最显着相关。非纤维组织和纤维组织外观之间的生物力学行为差异不太明显。通过血管内超声成像可以预测人体动脉粥样硬化组织的重要生物力学行为；这项技术可以对患病人类动脉的应力-应变关系进行详细的体内评估。
Intravascular ultrasound may be useful for studying the natural history of atherosclerotic lesions of different morphologies and for guiding interventional strategies. This study was designed to test the hypothesis that tissue appearance by intravascular ultrasound is related to the biomechanical properties of atheroma components. Forty-three atheroma caps were obtained from the abdominal aortas of 22 patients at autopsy and studied with an ultrasensitive, servo-controlled spectrometer. By measuring the static strain caused by increasing levels of compressive stress from 30 to 90 mm Hg, the uniaxial unconfined compression stiffness (ratio of stress to strain) was determined. After mechanical testing, specimens were imaged with a 6F, 20-MHz intravascular ultrasound transducer, and images were interpreted by an investigator who was unaware of the mechanical measurements. Specimens were classified as nonfibrous (n = 14), fibrous (n = 18), or calcified (n = 11) based on intravascular ultrasound appearance. The static stiffnesses of the nonfibrous, fibrous, and calcified ultrasound classes were 41.2 +/- 18.8 kPa, 81.7 +/- 33.2 kPa, and 354.5 +/- 245.4 kPa, respectively (p = 0.0002 by analysis of variance). The times to reach static equilibrium (creep time) for the nonfibrous, fibrous, and calcified classes were 79.6 +/- 26.5 minutes, 50.2 +/- 20.0 minutes, and 19.4 +/- 8.1 minutes, respectively (p = 0.0007). Intravascular ultrasound appearance was most significantly related to biomechanical behavior when calcium deposits were noted; the differences in biomechanical behavior between nonfibrous and fibrous tissue appearances were less apparent. Important biomechanical behavior of human atherosclerotic tissue can be predicted by intravascular ultrasound imaging; this technology may allow a detailed in vivo assessment of the stress-strain relation in diseased human arteries.