Administration of Soft Matter Lipid-DNA Nanoparticle As the Immunostimulant via Multiple Routes of Injection in Vivo
Administration of Soft Matter Lipid-DNA Nanoparticle As the Immunostimulant via Multiple Routes of Injection in Vivo
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DOI：
10.1021/acsbiomaterials.7b00440
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发表时间：
2017-09-01
影响因子：
5.8
通讯作者：
Lee, Peter C. W.
中科院分区：
文献类型：
--
作者：
Jin, Jun-O;Kwak, Minseok;Lee, Peter C. W.
我们阐明了适当的途径注射脂质-DNA胶束配制的寡核苷酸免疫佐剂在幼稚和荷瘤小鼠。我们在此报告，在评估了六种免疫刺激性纳米颗粒（INP）的给药方式后，几种注射途径有效地诱导了树突状细胞介导的体内免疫刺激，使其适用于使用此类DNA材料的癌症免疫疗法和疫苗。
We elucidated the proper routes for injecting lipid-DNA micelles formulated with an oligonucleotide immune adjuvant in naive and tumor-bearing mice. We report herein that after assessing six ways of administering an immunostimulatory nanoparticle (INP), several of the injection routes effectively induced dendritic cell-mediated immune-stimulation in vivo, making them amenable to cancer immunotherapies and vaccines using such DNA materials.