P1 plasmid maintenance: a paradigm of precise control.
P1 plasmid maintenance: a paradigm of precise control.
复制标题
P1 质粒维护：精确控制的范例。
DOI：
10.1007/978-1-4613-2447-8_27
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Yarmolinsky,MB
中科院分区：
文献类型：
--
作者：
Chattoraj,DK;Abeles,AL;Yarmolinsky,MB
概述某些细菌质粒，其中包括 P1 前噬菌体，尽管拷贝数非常低，但仍能稳定遗传 (59)。在每个溶原细胞中，保证细胞分裂前 P1 复制和细胞分裂时子质粒均分的机制以与突变率相当的错误频率运行 (7,61)。在回顾我们对如何实现这种保真度的了解时，本文将集中讨论质粒复制及其控制；奥斯汀和阿贝尔斯的随附一篇将考虑分区。
OverviewCertain bacterial plasmids, P1 prophage among them, are stably inherited despite their very low copy number (59). In each lysogenicCell, the mechanisms that guarantee a P1 replication prior toCelldivision and an equipartition of the daughter plasmids atCelldivision operate with error frequencies comparable to rates of mutation (7,61). In reviewing what we know about how such fidelity is achieved, this article will concentrate on plasmid replication and its control; the accompanying one by Austin and Abeles will consider partitioning.