Pre-operative predictors of short-term survival after pancreatic cancer resection.

Pre-operative predictors of short-term survival after pancreatic cancer resection.
复制标题

胰腺癌切除术后短期生存的术前预测因素。

DOI：
--
复制
发表时间：
1998
期刊：
Hepato-Gastroenterology
影响因子：
--
通讯作者：
H. Katoh
H. Katoh
中科院分区：
--
文献类型：
--
作者：
M. Takeuchi;S. Kondo;H. Sugiura;H. Katoh

文献摘要

被引文献

相似文献

背景/目的 本研究的目的是探讨影响胰腺癌切除术后短期生存的术前因素，并评估其预后价值。 方法 本文回顾了1989 ~ 1996年间在北海道大学附属医院第二外科手术治疗的59例胰腺导管腺癌患者。 结果 患者的平均年龄为62.6岁。年龄小于等于62岁的患者与年龄较大的患者之间的生存率差异显著（p=0.0053）。增强CT检查评估原发肿瘤大小; 36例患者肿瘤直径大于3 cm。肿瘤直径小于等于3 cm的患者的1年生存率明显优于原发肿瘤直径大于3 cm的患者（p=0.0258）。癌胚抗原（CEA）分析显示，术前值低于诊断临界值（临界指数; C.I.）2倍的患者1年生存率有显著差异。和值高于该水平的患者（p=0.0006）。肿瘤较小（≤ 3 cm）且术前血清CEA水平较低（≤ 2倍C.I.）的年轻患者（≤ 62岁）亚组的1年生存率，为72.7%（n=11）。多因素分析表明，年龄和术前血清CEA水平都是1年生存率的独立预后因素（分别为p=0.0077和0.003），尽管肿瘤大小的统计学意义较弱（p=0.107）。 结论 提示年龄和血清CEA水平是影响胰腺癌术后近期生存的独立预后因素。
BACKGROUND/AIMS The aim of the present study is to investigate the pre-operative factors that affect short-term survival after pancreatic cancer resection and to evaluate their prognostic value. METHODOLOGY Fifty-nine patients with ductal adenocarcinoma of the pancreas operated on in the Second Department of Surgery, Hokkaido University Hospital between 1989 and 1996 were reviewed. RESULTS The patients had a mean age of 62.6 years. The difference of survival between patients aged 62 years or younger and older patients was significant (p=0.0053). Primary tumor size was evaluated with enhanced CT examination; 36 patients had tumors larger than 3 cm in diameter. The 1-year survival rate of patients with tumors 3 cm or less in diameter was significantly better than that of patients with primary tumors greater than 3 cm in diameter (p=0.0258). Analysis of carcinoembryonic antigen (CEA) showed a significant difference in 1-year survival rates between patients with a pre-operative value below twice the diagnostic cutoff level (cutoff index; C.I.) and patients with a value above this level (p=0.0006). The 1-year survival rate for the subset of younger patients (= or < 62 years) with smaller tumors (3 cm or less) and a lower pre-operative serum CEA level (= or < two times of C.I.), was 72.7% (n=11). Multivariate analysis indicated that age and the pre-operative serum CEA level were both independent prognostic factors of 1-year survival (p=0.0077, and 0.003, respectively), although the statistical significance of tumor size was weak (p=0.107). CONCLUSIONS It was suggested that age and serum CEA level were independent prognostic factors of short-term survival after pancreatic cancer resection.