Control of neurotransmission by prostaglandins in canine trachealis smooth muscle.
Control of neurotransmission by prostaglandins in canine trachealis smooth muscle.
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前列腺素对犬气管平滑肌神经传递的控制。
DOI：
10.1152/jappl.1984.57.1.129
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Nadel,JA
中科院分区：
文献类型：
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作者：
Walters,EH;O'Byrne,PM;Fabbri,LM;Graf,PD;Holtzman,MJ;Nadel,JA
犬气管平滑肌对电场刺激的收缩反应在 2 小时的孵育期间减弱。然而，在相似的时间内添加吲哚美辛（10(-5) M）不仅阻止了这种收缩反应的抑制，而且实际上显着增加了对电场刺激的反应，表明前列腺素是造成时间依赖性抑制的原因。在对照组织中，在组织浴中测量的前列腺素 E2 在 2 小时内增加。向组织中添加前列腺素 E2 以浓度依赖性方式产生类似的对电场刺激的收缩反应的抑制。相反，单独孵育、吲哚美辛处理或添加前列腺素 E2 对乙酰胆碱诱导的收缩几乎没有影响（如果有的话）。我们的结论是，随着时间的推移，犬气管平滑肌中前列腺素的释放对交界前部位的胆碱能神经传递具有主要的抑制作用。
Contractile responses of canine tracheal smooth muscle to electrical field stimulation diminished over a 2-h period of incubation. However, addition of indomethacin (10(-5) M) for a similar time not only prevented this inhibition of contractile response, but actually markedly increased the response to electrical field stimulation, suggesting that prostaglandins were responsible for the time-dependent inhibition. Measured prostaglandin E2 increased in the tissue bath over 2 h in control tissues. Addition of prostaglandin E2 to the tissue produced similar inhibition of contractile responses to electrical field stimulation in a concentration-dependent manner. In contrast, incubation alone, treatment with indomethacin, or addition of prostaglandin E2 had little, if any, effect on contractions induced by acetylcholine. We conclude that the release of prostaglandins from canine tracheal smooth muscle that occurs with time has a predominantly inhibitory effect on cholinergic neurotransmission at a prejunctional site.