Non-alcoholic fatty liver disease is associated with higher levels of objectively measured sedentary behaviour and lower levels of physical activity than matched healthy controls.
Non-alcoholic fatty liver disease is associated with higher levels of objectively measured sedentary behaviour and lower levels of physical activity than matched healthy controls.
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DOI：
10.1136/flgastro-2014-100432
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发表时间：
2015-01
影响因子：
2.6
通讯作者：
Trenell MI
中科院分区：
文献类型：
--
作者：
Hallsworth K;Thoma C;Moore S;Ploetz T;Anstee QM;Taylor R;Day CP;Trenell MI
身体活动是代谢控制的关键决定因素，建议非酒精性脂肪肝（NAFLD）患者，通常伴随体重减轻和饮食改变。迄今为止，没有研究报告客观测量的久坐行为与NAFLD患者的身体活动，肝脏脂肪和代谢控制之间的关系，限制了在临床实践中靶向久坐行为的潜力。这项研究确定了NAFLD患者的久坐行为和体力活动水平，并调查了体力活动，肝脏脂肪和葡萄糖控制之间的联系。使用经过验证的多传感器阵列在7天内对37名NAFLD成人的久坐行为、体力活动和能量消耗进行了评估。 分别通过1H-MRS和空腹血液样本评估肝脏脂肪和葡萄糖控制。久坐行为的模式进行了评估，从原始久坐数据拟合久坐发作的长度的幂律分析。年龄和性别匹配的健康对照组在相同的时间段内佩戴活动监测器。NAFLD患者每天多花大约半小时久坐（1318±68 vs 1289 ±60分钟/天; p<0.05），步行步数减少18%（8483±2926 vs 10377±3529步/天; p<0.01）。 因此，NAFLD患者的活动能量消耗减少了40%（432±258与732±345千卡/天; p<0.01），总能量消耗较低（2690±440与2901±511千卡/天; p<0.01）。 对久坐发作时间的幂律分析表明，与对照组相比，NAFLD患者从久坐到活动的转换次数也较低（13± 0.03% vs 15 ±0.03%; p<0.05）。与健康对照组相比，NAFLD患者每天久坐的时间更长，体力活动更少。高水平的久坐行为和低水平的体力活动代表了一个治疗目标，可以防止NAFLD患者的代谢状况和体重增加的进展，并应在临床护理中考虑。
Physical activity is a key determinant of metabolic control and is recommended for people with non-alcoholic fatty liver disease (NAFLD), usually alongside weight loss and dietary change. To date, no studies have reported the relationship between objectively measured sedentary behaviour and physical activity, liver fat and metabolic control in people with NAFLD, limiting the potential to target sedentary behaviour in clinical practice. This study determined the level of sedentary behaviour and physical activity in people with NAFLD, and investigated links between physical activity, liver fat and glucose control. Sedentary behaviour, physical activity and energy expenditure were assessed in 37 adults with NAFLD using a validated multisensor array over 7 days. Liver fat and glucose control were assessed, respectively, by 1H-MRS and fasting blood samples. Patterns of sedentary behaviour were assessed by power law analyses of the lengths of sedentary bouts fitted from raw sedentary data. An age and sex-matched healthy control group wore the activity monitor for the same time period. People with NAFLD spent approximately half an hour extra a day being sedentary (1318±68 vs1289±60 mins/day; p<0.05) and walked 18% fewer steps (8483±2926 vs 10377±3529 steps/day; p<0.01). As a consequence, active energy expenditure was reduced by 40% (432±258 vs 732±345 kcal/day; p<0.01) and total energy expenditure was lower in NAFLD (2690±440 vs 2901±511 kcal/day; p<0.01). Power law analyses of the lengths of sedentary bouts demonstrated that patients with NAFLD also have a lower number of transitions from being sedentary to active compared with controls (13±0.03 vs15±0.03%; p<0.05). People with NAFLD spend more time sedentary and undertake less physical activity on a daily basis than healthy controls. High levels of sedentary behaviour and low levels of physical activity represent a therapeutic target that may prevent progression of metabolic conditions and weight gain in people with NAFLD and should be considered in clinical care.